Results 121 to 130 of about 745,289 (215)

Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

, 2018
Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. In recent years, some nonimmunoglobulin alternative scaffold affinity proteins, such as affibody molecules and ADAPTs, have emerged and ...
openaire   +1 more source

Site-Specific Glycan Conjugation Improves Stability and Efficacy of an Antibody-Drug Conjugates Bearing DXd as a Cytotoxic Payload. [PDF]

ACS Omega
Manabe S, Senga S, Iwamoto S, Yarita H, Takahashi R, Mitani A, Sumiyoshi W, Hoshinoo A, Hiranyakorn M, Kinoshita T, Yoshimura C.   +10 more
europepmc   +1 more source

DNA-programmed bispecific peptide assemblies for delivering cytotoxic payload to cells expressing EGFR and MET receptors. [PDF]

RSC Chem Biol
Ghosh P, Dinh H, Seitz O.
europepmc   +1 more source

Killing cancer cells by targeted drug-carrying phage nanomedicines [PDF]

, 2008
Hagit Bar, Iftach Yacoby, Itai Benhar
core   +1 more source

Data from A Dual-Payload Antibody–Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer

<div>Abstract<p>Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous disease that often relapses following treatment with standard radiotherapies and cytotoxic chemotherapies. Combination therapies have potential for treating refractory metastatic TNBC.
Xiaoguang “Margaret” Liu, Lufang Zhou, Seulhee Kim, Ashley George, Kai Chen, Jiashuai Zhang, Yingnan Si, Zhuoxin “Zora” Zhou   +7 more
openaire   +1 more source

Overcoming resistance to antibody-drug conjugates: mechanisms and emerging strategies. [PDF]

Oncologist
Inase A, Kimbara S, Imamura E, Phelps MA, Minami H.   +4 more
europepmc   +1 more source

1081 CD25-specific aptamer conjugated with cytotoxic payloads shows the potential to modulate immune-suppressive environment in tumors by depleting Tregs selectively

Regular and Young Investigator Award Abstracts, 2023
Daekyun Lee, Ju-hyung Kang, Inu Song
openaire   +2 more sources

Biophysical and Structural Characterization of Antibody-Drug Conjugates. [PDF]

Cancers (Basel)
Mariano IP, Nath A.
europepmc   +1 more source

Focusing on toxicity management: Challenges and strategies for HER2-targeted antibody-drug conjugates in breast cancer. [PDF]

Breast
Liu X, Yin S, Li X, Nie J.
europepmc   +1 more source