Results 111 to 120 of about 1,036,342 (307)
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Datopotamab deruxtecan induces hallmarks of immunogenic cell death
Cell StressAntibody-drug conjugates (ADCs) offer a strategy for targeted delivery of cytotoxic agents to cancer cells. In this study, we investigated the mechanism of action of datopotamab deruxtecan, an ADC composed of a monoclonal antibody targeting tumor ...
Sabrina Forveille +4 more
doaj +1 more source
Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class.
Angewandte Chemie, 2018 The number of cytotoxic payload classes successfully employed in antibody-drug conjugates (ADCs) is still rather limited. The identification of ADC payloads with a novel mode of action will increase therapeutic options and potentially increase the ...
H. Lerchen +11 more
semanticscholar +1 more source
Simulasi Dan Analisis Uji Fungsional Homing Meteo Payload Roket Kompetisi
, 2010 Sebelum uji terbang, semua homing meteo payload roket harus menjalani uji fungsional mencakup uji statik dan uji dinamik. Uji statik terdiri atas G-shock, vibrasi dan G-Force adalah untuk mengetahui fungsi telecommand ketika muatan diberi hentakan ...
Eko Budi Purwanto
core
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Frontiers in ImmunologyAntibody-drug conjugates (ADCs) offer selective delivery of potent cytotoxic payloads to tumour-associated antigens and are therefore attractive candidates for biomarker-informed treatment development.
Shuyu Ren, Fangfang Pan, Jie Jin
doaj +1 more source
Blood Advances, 2018 : The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus
Yelena Kovtun +16 more
doaj +1 more source
Advanced Science, EarlyView.Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim +9 more
wiley +1 more source
STS-51 AFT Payload Operating Procedure Partial
, 1984 AFT Payload Operating Procedure dated October 1 ...
core
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source