Results 121 to 130 of about 1,036,342 (307)

Value of Antibody Drug Conjugates for Gynecological Cancers: A Modern Appraisal Following Recent FDA Approvals

International Journal of Women's Health, 2023
Blair McNamara, Yifan Chang, Ashley Goreshnik, Alessandro D Santin Department of Obstetrics, Gynecology, and Reproductive Sciences Yale University School of Medicine, New Haven, CT, 06520, USACorrespondence: Alessandro D Santin, Obstetrics and Gynecology,
McNamara B, Chang Y, Goreshnik A, Santin AD   +3 more
doaj  

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Frontiers in Antibody–Drug Conjugates: Mechanisms, Design Innovations, and Clinical Applications in Targeted Cancer Therapy

Pharmaceuticals
Antibody–drug conjugates (ADCs) represent a transformative class of targeted therapies designed to deliver potent cytotoxic agents specifically to tumor cells, minimizing systemic toxicity. This review provides a comprehensive overview of ADCs, detailing
Xinghan Li, Jiaming Liu, Yitong Meng, Jun Li, Jieling Zhao, Dequan Liu, Xiaodong Zhang   +6 more
doaj   +1 more source

The TerraSAR-X Ground Segment [PDF]

, 2006
The Ground Segment of the TerraSAR-X mission provides the infrastructure required to command and control the satellite and the instrument, to receive user requests, to process and archive the acquired data and to deliver the image products.
Werninghaus, Rolf, Mittermayer, Josef, Buckreuss, Stefan, Mühlbauer, Peter, Balzer, Wolfgang   +4 more
core  

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Pharmacophore-Based Structure Optimization of S-Trityl-l-Cysteine Derivatives for Cytotoxic Payload Applications

ACS Medicinal Chemistry Letters
Kinesin spindle protein (KSP) represents a promising target for cancer therapy with a mechanism of action distinct from conventional microtubule agents. We previously identified S-trityl-L-cysteine (STLC) derivatives as potent and selective KSP inhibitors.
Taiki Ichida, Naohisa Ogo, Keisuke Murase, Ryota Fukai, Jun-ichi Sawada, Hisashi Murakami, Akira Asai   +6 more
openaire   +4 more sources

Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

International Journal of Molecular Sciences, 2017
Antibody-drug conjugates (ADCs), designed to selectively deliver cytotoxic agents to antigen-bearing cells, are poised to become an important class of cancer therapeutics.
Yan-Ming Wang, Shiyong Fan, Wu Zhong, Xin-Bo Zhou, Song Li   +4 more
semanticscholar   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Perancangan Peredam untuk Melindungi Payload Roket dari gangguan Shock dan Vibrasi

, 2012
Durasi yang penting dan sangat menentukan pada peluncuran roket adalah saat mulainya meluncur sampai habis terbakar, yaitu burning time. Pada durasi tersebut motor roket menimbulkan getaran yang menggetarkan seluruh roket beserta isinya.
Wahyu Widada, Andreas Prasetya Adi, Sutrisno   +2 more
core  

Experience of passive thermal control of long-term near- Earth small satellite mission [PDF]

, 2013
The microsatellite BIRD (Bispectral InfraRed Detection) with mass of 94 kg and overall sizes 0.55 x 0.61 x 0.62 m operates on near-Earth sun-synchronous orbit more than 11 years.
Baturkin, Volodymyr, Lötzke, Horst Georg, Lötzke, Horst-Georg, Biering, Bernd, Lura, Franz   +4 more
core