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Effect of using different co-ligands during 99mTc-labeling of J18 peptide on SK-MES-1 cell binding and tumor targeting [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Lung cancer is the main cause of cancer death, and its incidence is increasing worldwide. The goal of this study is to evaluate in vitro and in vivo tumor targeting behavior of [99mTc]Tc -HYNIC-(Ser)3-J18 in lung carcinoma (SK-MES-1 ...
Seyed Jalal Hosseinimehr +3 more
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Antibody–Drug Conjugates—A Tutorial Review
Molecules, 2021 Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 ADCs currently in clinical development and eleven ADCs (nine containing small ...
Stephanie Baah +2 more
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Resource for FRET-Based Biosensor Optimization
Frontiers in Cell and Developmental Biology, 2022 After the development of Cameleon, the first fluorescence resonance energy transfer (FRET)-based calcium indicator, a variety of FRET-based genetically encoded biosensors (GEBs) have visualized numerous target players to monitor their cell physiological ...
Heonsu Kim +5 more
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How Far Have We Developed Antibody–Drug Conjugate for the Treatment of Cancer?
Drugs and Drug Candidates, 2023 Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells is that cancerous cells often overexpress protein on the cell membrane—for instance, the overexpression of human epidermal ...
Yu Jun Lim +10 more
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Pharmaceuticals, 2023 PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology and drug discovery. This technique facilitates the complete removal of the target proteins that are “undruggable” or challenging to target through chemical molecules via
Danishuddin +5 more
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Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions
Viruses, 2021 In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin content.
Nidhi Mittal +9 more
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Arginine 37 of Glycine Linker Dictates Regulatory Function of HapR
Frontiers in Microbiology, 2020 HapR is designated as a high cell density quorum sensing master regulatory protein of Vibrio cholerae. It is a member of the TetR family protein and functions both as an activator and a repressor by directly communicating with cognate promoters, thus ...
Manjula Ekka +5 more
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Trends in the Development of Antibody-Drug Conjugates for Cancer Therapy
Antibodies, 2023 In cancer treatment, the first-generation, cytotoxic drugs, though effective against cancer cells, also harmed healthy ones. The second-generation targeted cancer cells precisely to inhibit their growth.
Chi Hun Song +5 more
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Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents
Molecules, 2018 Three series of N-(pyrazin-2-yl)benzamides were designed as retro-amide analogues of previously published N-phenylpyrazine-2-carboxamides with in vitro antimycobacterial activity. The synthesized retro-amides were evaluated for in vitro growth inhibiting
Jan Zitko +7 more
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Marine Drugs, 2019 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are involved in fast synaptic transmission and mediated physiological activities in the nervous system.
Xiaoxiao Xu +4 more
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