Results 21 to 30 of about 255,199 (267)

Trends in the Development of Antibody-Drug Conjugates for Cancer Therapy

Antibodies, 2023
In cancer treatment, the first-generation, cytotoxic drugs, though effective against cancer cells, also harmed healthy ones. The second-generation targeted cancer cells precisely to inhibit their growth.
Chi Hun Song, Minchan Jeong, Hyukmin In, Ji Hoe Kim, Chih-Wei Lin, Kyung Ho Han   +5 more
doaj   +1 more source

Functionalization of Iron Nanoparticles with Linkers for Removal of Pollutants in Water [PDF]

Water Harvesting Research, 2022
Today, quality monitoring of water resources played an influential role in its exploitation and use. Water sources usually contain heavy metals in minor concentrations.
Raziyeh Shamshirgaran, Reihaneh Malakooti, Abolfazl Akbarpour, Ali Zeraatkar Moghaddam   +3 more
doaj   +1 more source

Linker Histone in Diseases [PDF]

International Journal of Biological Sciences, 2017
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases.
Ye, Xin, Feng, ChuanLin, Gao, Tian, Mu, Guanqun, Zhu, Weiguo, Yang, Yang   +5 more
openaire   +2 more sources

The control technology of harmful substances impacting the quality of peanut oil: A review

Grain & Oil Science and Technology
Peanut is a globally important leguminous crop and one of the most important oil crops. In response to the growing demand for high-quality peanut oil, advancements in processing technologies have led to significant improvements in oil quality.
Zifu Ni, Xiao Ouyang, Azhen Nie, Lina Huang, Ruoqi Li, Jinling Li, Peng Chen   +6 more
doaj   +1 more source

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

Molecules, 2017
Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen, Zongtao Lin, Kinsie E. Arnst, Duane D. Miller, Wei Li   +4 more
doaj   +1 more source

Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies

Pharmaceuticals
Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in
Vitor Martins de Almeida, Milena Botelho Pereira Soares, Osvaldo Andrade Santos-Filho   +2 more
doaj   +1 more source

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity.
Wenli Fan, Lin Zhang, Xuejiang Wang, Haiyong Jia, Lei Zhang   +4 more
doaj   +1 more source

Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline

Molecules, 2020
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(
Ahmed T. A. Boraei, Ahmed A. M. Sarhan, Sammer Yousuf, Assem Barakat   +3 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

OmDet: Large‐scale vision‐language multi‐dataset pre‐training with multimodal detection network

IET Computer Vision
The advancement of object detection (OD) in open‐vocabulary and open‐world scenarios is a critical challenge in computer vision. OmDet, a novel language‐aware object detection architecture and an innovative training mechanism that harnesses continual ...
Tiancheng Zhao, Peng Liu, Kyusong Lee
doaj   +1 more source