Results 11 to 20 of about 255,199 (267)
Progresses in research and development of antibody-drug conjugate
生物医学转化, 2021 Through referring to the literature and related databases, the research process of antibodyconjugated drugs was reviewed, and the key elements of ADC were summarized.
Wu Gang +6 more
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Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents
Molecules, 2018 Three series of N-(pyrazin-2-yl)benzamides were designed as retro-amide analogues of previously published N-phenylpyrazine-2-carboxamides with in vitro antimycobacterial activity. The synthesized retro-amides were evaluated for in vitro growth inhibiting
Jan Zitko +7 more
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Molecules, 2020 Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide–thiol reaction (Michael addition).
Chiara Da Pieve +5 more
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LINKER: a program to generate linker sequences for fusion proteins [PDF]
Protein Engineering, Design and Selection, 2000 The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally selected based on intuition. Without a reliable selection criterion, the design of such linkers is often difficult, particularly in situations where longer linker sequences
C J, Crasto, J A, Feng
openaire +2 more sources
Marine Drugs, 2019 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are involved in fast synaptic transmission and mediated physiological activities in the nervous system.
Xiaoxiao Xu +4 more
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Strategies for Expressing Possession in Some Iranian Linguistic Varieties [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2019 The present study aims at reviewing the strategies employed in some Iranian linguistic varieties in order to express possession. To do so, first the type of possessive strategy used in each variety was described based upon the categorization made by ...
Shahla Sharifi, Narjes Banoo Sabouri
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Drug Delivery, 2022 Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody–drug conjugates (ADCs) via the thiol-Michael click chemistry.
Yanming Wang +6 more
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Antibody–Drug Conjugates: The Last Decade
Pharmaceuticals, 2020 An armed antibody (antibody–drug conjugate or ADC) is a vectorized chemotherapy, which results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously constructed spacer arm.
Nicolas Joubert +3 more
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Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions
Viruses, 2021 In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin content.
Nidhi Mittal +9 more
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Molecules, 2018 Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect.
Anna Pawełczyk +3 more
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