Results 11 to 20 of about 331,196 (308)

Linker-Mediated Self-Assembly Dynamics of Charged Nanoparticles

, 2016
Using in situ liquid cell transmission electron microscopy (TEM), we visualized a stepwise self-assembly of surfactant-coated and hydrated gold nanoparticles (NPs) into linear chains or branched networks. The NP binding is facilitated by linker molecules,
Sanoj Raj (2937480), See Wee Chee (2607835), Utkur Mirsaidov (1343040), Guanhua Lin (1394581), Petr Král (1294236)   +4 more
core   +5 more sources

Cross-linker-Modulated Nanogel Flexibility Correlates with Tunable Targeting to a Sterically Impeded Endothelial Marker

, 2019
Deformability of injectable nanocarriers impacts rheological behavior, drug loading, and affinity target adhesion. Here, we present atomic force microscopy (AFM) and spectroscopy measurements of nanocarrier Young’s moduli, tune the moduli of deformable ...
Russell J. Composto (597535), Kelsey G. DeFrates (3965390), Bruce Braender (7485068), David M. Eckmann (302601), Jenna H. Towslee (7485062), Vladimir R. Muzykantov (171603), Jacob Wheatley Myerson (7485056), Olivia McPherson (7485059), Oscar A. Marcos-Contreras (7485065), Vladimir V. Shuvaev (469634)   +9 more
core   +3 more sources

RECONSTITUTION OF ALLOPHYCOCYANIN FROM Mastigocladus laminosus WITH ISOLATED LINKER POLYPEPTIDE [PDF]

, 1993
The core linker polypeptide Lc 8.9 was isolated from Mastigocladus laminosus and purified on a preparative scale. A method for the reconstitution of allophycocyanin (AP)—linker complexes from isolated polypeptides was developed. The complex (αAP(βAP)3 Lc
L. Gottschalk, F. Lottspeich, Scheer, Hugo, H. Scheer, Gottschalk, Lothar, Scherz, A.   +5 more
core   +1 more source

Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. [PDF]

, 2008
The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine ...
Villar-Garea, Ana, Imhof, Axel, Axel Imhof, Ana Villar-Garea   +3 more
core   +2 more sources

Primers used to amplify VL-linker-VH sequence.

, 2022
Primers used to amplify VL-linker-VH sequence.
Michele Menotta (55040), Tania Vanzolini (9227174), Mauro Magnani (120149), Rita Crinelli (144243), Filippo Tasini (14034794), Tomas Di Mambro (14034791), Barbara Canonico (166165), Marzia Bianchi (421126)   +7 more
core   +1 more source

LINKER: a program to generate linker sequences for fusion proteins [PDF]

Protein Engineering, Design and Selection, 2000
The construction of functional fusion proteins often requires a linker sequence that adopts an extended conformation to allow for maximal flexibility. Linker sequences are generally selected based on intuition. Without a reliable selection criterion, the design of such linkers is often difficult, particularly in situations where longer linker sequences
C J, Crasto, J A, Feng
openaire   +2 more sources

Linker-Dependent Folding Rationalizes PROTAC Cell Permeability [PDF]

, 2022
Proteolysis-targeting chimeras (PROTACs) must be cell permeable to reach their target proteins. This is challenging as the bivalent structure of PROTACs puts them in chemical space at, or beyond, the outer limits of oral druggable space.
Poongavanam, Vasanthanathan, Vasanthanathan Poongavanam, Stephan Siegel, Meibom, Daniel,, Giese, Anja,, Poongavanam, Vasanthanathan,, Erdélyi, Máté, Stephan Siegel (3989942), Siegel, Stephan, Jan Kihlberg (26018), Daniel Meibom, Atilaw, Yoseph,, Kihlberg, Jan,, Jan Kihlberg, Siegel, Stephan,, Anja Giese, Lehmann, Lutz,, Anja Giese (4243621), Lehmann, Lutz, Erdélyi, Máté,, Giese, Anja, Mate Erdelyi (1408990), Yoseph Atilaw (4250854), Atilaw, Yoseph, Yoseph Atilaw, Meibom, Daniel, Daniel Meibom (9473231), Mate Erdelyi, Lutz Lehmann (2153491), Kihlberg, Jan, Vasanthanathan Poongavanam (459234), Lutz Lehmann   +31 more
core   +2 more sources

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity.
Wenli Fan, Lin Zhang, Xuejiang Wang, Haiyong Jia, Lei Zhang   +4 more
doaj   +1 more source

Microwave (MW), Ultrasound (US) and Combined Synergic MW-US Strategies for Rapid Functionalization of Pharmaceutical Use Phenols

Molecules, 2018
Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect.
Anna Pawełczyk, Katarzyna Sowa-Kasprzak, Dorota Olender, Lucjusz Zaprutko   +3 more
doaj   +1 more source

Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline

Molecules, 2020
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(
Ahmed T. A. Boraei, Ahmed A. M. Sarhan, Sammer Yousuf, Assem Barakat   +3 more
doaj   +1 more source