Results 91 to 100 of about 1,036,342 (307)

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses [PDF]

, 2000
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK).
Anthony D. Kelleher, Jamie Wilson, Wayne Dyer, Sunil Shaunak, Phillips, Rodney, Sullivan, JS, Ian Jones, Workman, C, Rodney E. Phillips, Edward C. Holmes, Kelleher, AD, Christopher Conlon, Rachel L. Allen, John S. Sullivan, Conlon, C, Shaunak, S, Christian Brander, Kara Olson, Goulder, Philip, Allen, RL, Dyer, W, Olson, K, Graham Ogg, Brander, C, Philip Goulder, Mcmichael, Andrew, Ogg, G, Andrew J. McMichael, Long, C, Holmes, EC, Wilson, J, Goulder, P, Cassy Workman, Sarah Rowland-Jones, Rowland-Jones, S, McMichael, AJ, Jones, I, Phillips, RE, Chad Long   +38 more
core   +1 more source

A Superlubricated Magnetically Steerable Microcatheter with Integrated Optical and Fluidic Channels

Advanced Robotics Research, EarlyView.
A magnetically steerable microcatheter with integrated optical and fluidic channels is developed for multifunctional navigation in tortuous anatomical environments. A surface‐grafted hydrogel coating enables low‐friction actuation. The device demonstrates stable light and fluid delivery during magnetic manipulation, offering a compact platform for ...
Yuntian Du, Ruokun He, Luqi Li, Hesheng Wang, Zhuo‐Chen Ma, Bing Han   +5 more
wiley   +1 more source

Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-Lymphocyte responses in infected African and Caucasoid adults and children [PDF]

, 2000
Cytotoxic T-lymphocyte (CTL) activity plays a central role in control of viral replication and in determining outcome in cases of human immunodeficiency virus type 1 (HIV-1) infection.
Ogg, GS, Coovadia, HM, O'Callaghan, CA, Kalams, SA, Mngqundaniso, N., Altfeld, M.A., Hammond, M., He, S, He, S., O'Callaghan, C.A., Tang, Y, Burchett, S.A., Walker, B.D., Rosenberg, ES, Burchett, SA, Pelton, SI, McIntosh, K, Annamalai, K, Annamalai, K., Cao, H, Walker, BD, Bunce, M, McIntosh, K., Coovadia, H.M., Kalams, S.A., Rosenberg, E.S., Govender, U., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Hammond, M, O'Callaghan, Christopher, Mngqundaniso, N, Cao, H., Altfeld, MA, Ogg, G.S., Hartman, K.E., Pelton, S.I., Govender, U, Hartman, KE, Tang, Y., Bunce, M.   +42 more
core   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Antibody–Drug Conjugates (ADCs): A Review of Structural Design, Technological Evolution, and Future Perspectives

Molecules
Antibody–drug conjugates (ADCs) have become an important class of targeted anticancer therapeutics by integrating the tumor selectivity of monoclonal antibodies with the potent cytotoxicity of small-molecule payloads through rational linker design.
Guiying Wu, Zhenhai Yuan, Ming Chen, Xuan Tang, Fang Wang, Daizhou Zhang   +5 more
doaj   +1 more source

Novel antibody–drug conjugates for triple negative breast cancer

Therapeutic Advances in Medical Oncology, 2020
Triple negative breast cancer (TNBC) is a heterogenous subtype of breast cancer often associated with an aggressive phenotype and poor prognosis. Antibody–drug conjugate (ADC), comprising of a monoclonal antibody linked to a cytotoxic payload by a linker,
Aiko Nagayama, Neelima Vidula, Leif Ellisen, Aditya Bardia   +3 more
doaj   +1 more source

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.

Cancer Research, 2016
Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood.
Fu Li, Kim K. Emmerton, M. Jonas, Xinqun Zhang, J. Miyamoto, J. Setter, Nicole D. Nicholas, N. Okeley, Robert P. Lyon, Dennis R. Benjamin, C. Law   +10 more
semanticscholar   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology
Antibody–drug conjugates (ADCs) are rapidly expanding in the clinical treatment of cancers, and combinations with checkpoint inhibitors further enhance antitumor activity in patients sensitive to such immunotherapy. However, a method to improve treatment durability, including cases where immunologically cold tumors limit checkpoint inhibitor activity ...
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
openaire   +2 more sources

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

Scientific Reports, 2018
Synthetic pyrrolobenzodiazepine (PBD) dimers, where two PBD monomers are linked through their aromatic A-ring phenolic C8-positions via a flexible propyldioxy tether, are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity ...
J. Hartley, M. Flynn, J. Bingham, Simon Corbett, Halla W. Reinert, A. Tiberghien, Luke A. Masterson, Dyeison Antonow, Lauren Adams, Sajidah Chowdhury, David G. Williams, Shen-Lan Mao, Jay Harper, C. Havenith, F. Zammarchi, S. Chivers, P. V. van Berkel, P. Howard   +17 more
semanticscholar   +1 more source