Results 81 to 90 of about 1,036,342 (307)

A mechanistic tumor penetration model to guide antibody drug conjugate design. [PDF]

PLoS ONE, 2015
Antibody drug conjugates (ADCs) represent novel anti-cancer modalities engineered to specifically target and kill tumor cells expressing corresponding antigens.
Christina Vasalou, Gabriel Helmlinger, Bruce Gomes   +2 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Recent Technological and Intellectual Property Trends in Antibody–Drug Conjugate Research

Pharmaceutics
Antibody–drug conjugate (ADC) therapy, an advanced therapeutic technology comprising antibodies, chemical linkers, and cytotoxic payloads, addresses the limitations of traditional chemotherapy. This study explores key elements of ADC therapy, focusing on
Youngbo Choi, Youbeen Choi, Surin Hong
doaj   +1 more source

Trojan horses at leptomeningeal cellular gates: Antibody–drug conjugates deliver cytotoxic payloads

Med
The DEBBRAH study showed promising results for patients with HER2-expressing (including HER2-low) metastatic breast cancer who received the antibody-drug conjugate (ADC) trastuzumab deruxtecan for leptomeningeal disease. ADCs represent a novel tool in the precision biomarker-based armamentarium, including in the tumor-agnostic setting, for targeting ...
Nikanjam, Mina, Kurzrock, Razelle
openaire   +2 more sources

Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure

International Journal of Molecular Sciences
Antibody–drug conjugates (ADCs) are promising cancer therapeutics, but optimizing their cytotoxic payloads remains challenging. We present DumplingGNN, a novel hybrid Graph Neural Network architecture for predicting ADC payload activity and toxicity ...
Shengjie Xu, Lingxi Xie, Rujie Dai, Zehua Lyu   +3 more
semanticscholar   +1 more source

De Novo generation of escape Variant-specific CD8+ T-Cell responses following Cytotoxic T-Lymphocyte escape in chronic Human Immunodeficiency Virus Type 1 Infection [PDF]

, 2005
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell responses to such mutants.
Allgaier, R.L., Cheng, M., Galit Alter, Altfeld, M., Elizabeth T. Kalife, Frahm, N., Xu G. Yu, Kalife, E.T., Marcus Altfeld, Michael Cheng, Yu, X.G., Walker, B.D., Laura L. Reyor, Mui, S., Allen, T.M., Reyor, L.L., Christian Brander, Alter, G., Mathias Lichterfeld, Eric S. Rosenberg, Rachel L. Allgaier, Todd M. Allen, Simon A. Mallal, Nancy V. Brown, John, M., Nicole Frahm, Johnston, M.N., Rosenberg, E.S., Brown, N.V., Brander, C., Bruce D. Walker, Mina John, Mary N. Johnston, Mallal, S.A., Stanley Mui, Lichterfeld, M.   +35 more
core   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

A Dual-Payload Antibody–Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer

Cancer Research
An anti-CD276 monoclonal antibody conjugated with both a cytotoxic drug and an immune boosting reagent effectively targets triple-negative breast cancer by inducing tumor cell death and stimulating immune cell infiltration.
Zhuoxin Zhou, Yingnan Si, Jiashuai Zhang, Kai Chen, Ashley George, Seulhee Kim, Lufang Zhou, X. Liu   +7 more
semanticscholar   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Homogeneous Dual-Payload Antibody-Drug Conjugates Produced by Combined Distinct Conjugation Strategies.

ACS Medicinal Chemistry Letters
Antibody-drug conjugates (ADCs) represent a promising class of targeted cancer therapies, combining monoclonal antibody specificity with cytotoxic drug potency.
Tomohiro Watanabe, Yusuke Iwai, J. Stofleth, Tomohiro Fujii, Takuya Seki, Yutaka Matsuda   +5 more
semanticscholar   +1 more source