Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
Molecular Therapy: Methods & Clinical Development, 2017 There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constructed
Daniel J. Woodsworth +3 more
doaj +1 more source
OncoImmunology, 2022 Antibody–drug conjugates (ADCs) are used to target cancer cells by means of antibodies directed to tumor-associated antigens, causing the incorporation of a cytotoxic payload into target cells.
Anette Sommer +7 more
doaj +1 more source
SYNTHESIS OF RGD PEPTIDOMIMETIC-DRUG CONJUGATES FOR THE TUMOR-TARGETED DELIVERY OF CYTOTOXIC AGENTS [PDF]
, 2018 Integrins are a large family of heterodimeric transmembrane glycoprotein receptors, composed by two non-covalently associated subunits (α and β). Integrins αVβ3 and αVβ5 are overexpressed on blood vessels in human tumors but not on vessels in normal ...
RAPOSO MOREIRA DIAS, ANDRE FILIPE
core +1 more source
Design neuer bi- und trispezifischer Antikörperderivate für die zielgerichtete Applikation haptenylierter toxischer Payloads [PDF]
, 2020 Hapten bindende bispezifische Antikörper (bsAbs), die sowohl Oberflächenantigene als auch haptenylierte Payloads binden, können für den zielgerichteten Transport von Payload- Molekülen zu Tumorzellen genutzt werden.
Adelmann, Juliane
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Indian Journal of Medical and Paediatric Oncology, 2020 Antibody drug conjugates (ADCs) are chemically engineered drugs consisting of monoclonal antibody (mAb) and cytotoxic compound attached chemically by a linker. Upon attachment to a specific target antigen, ADC enters into the cell and payload is released,
Stalin Bala, Siva K Prasad
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure [PDF]
Antibody–drug conjugates (ADCs) are promising cancer therapeutics, but optimizing their cytotoxic payloads remains challenging. We present DumplingGNN, a novel hybrid Graph Neural Network architecture for predicting ADC payload activity and ...
Lingxi Xie +3 more
core +1 more source
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug [PDF]
, 2009 The dose-limiting toxicity of chemotherapeutics, heterogeneity and drug resistance of cancer cells, and difficulties of targeted delivery to tumors all pose daunting challenges to effective cancer therapy.
Kartini Kochar +25 more
core +1 more source
Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies [PDF]
, 2022 With a wide range of available cytotoxic therapeutics, the main focus of current cancer research is to deliver them specifically to the cancer cells, minimizing toxicity against healthy tissues.
Jakub Szymczyk (11685346) +13 more
core +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source