Results 261 to 270 of about 15,170 (273)

Abstract 2056: Click chemistry enabled selective activation of highly cytotoxic MMAE payload at tumors using TROP2 targeting agent

Cancer Research
Abstract Shasqi is advancing the Click Activated Protodrugs Against Cancer (CAPAC®) platform based on click chemistry, a Nobel Prize winning technology. The platform is modular and comprises 1) an activator that target specific antigens, and 2) inert cancer drugs, protodrugs, which are selectively activated at tumors via click chemistry.
George Coricor, Jesse M. McFarland, Sangeetha Srinivasan, Stefanie Wagner, Tri-Hung Nguyen, Jose M. Mejia Oneto   +5 more
openaire   +1 more source

Antibody Drug Conjugates with a Novel Translation Inhibitor Payload Demonstrate Cytotoxicity and Tumor Growth Reduction in Multiple Myeloma Models

Blood
Background Antibody drug conjugates (ADCs) are a validated modality for the targeted delivery of cytotoxic payloads to myeloma cells while sparing healthy tissue. To achieve the full potential of ADCs in multiple myeloma patients, it will be important to have ADCs that incorporate payloads with ...
openaire   +1 more source

Development of novel cryptophycins as cytotoxic payloads for tumor targeting

2022
Schachtsiek, Thomas, Dessin, Cedric, Sewald, Norbert   +2 more
openaire   +1 more source

Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2015
Huidong Gu, Alexander Kozhich, Anne-Françoise Aubry   +2 more
exaly  

Unconjugated Payload Quantification and Dar Characterization of Antibody–Drug Conjugates Using High-Resolution MS

Bioanalysis, 2016
Frank Barletta, Joseph Tweed, Cong Wei   +2 more
exaly  

An antibody–cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours

European Journal of Cancer, 2011
Michele Sanicola
exaly  

Affibody-mediated peptide nucleic acid pretargeting for delivery of cytotoxic payloads to HER2 positive carcinoma

Proceedings of the 37th European Peptide Symposium
Jacob Clinton, Kristina Westerlund, Amelie Eriksson Karlström   +2 more
openaire   +1 more source

Dual-payload antibody–drug conjugates: Taking a dual shot

European Journal of Medicinal Chemistry
Yuxi Wang
exaly  

Risk of a Second Malignancy Related to the Use of Cytotoxic Chemotherapy

Ca-A Cancer Journal for Clinicians, 1982
exaly  

PayloadGenX, a multi-stage hybrid virtual screening approach for payload design: A microtubule inhibitor case study

Computational Biology and Chemistry
Kyung Hyun Choi, Faheem Ahmed
exaly