Results 21 to 30 of about 1,036,342 (307)
Introduction to Antibody-Drug Conjugates
Antibodies, 2021 Antibody-drug conjugates (ADCs) are innovative biopharmaceutical products in which a monoclonal antibody is linked to a small molecule drug with a stable linker.
Mark C. Pettinato
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Frontiers in Chemistry, 2022 An efficient Ugi multicomponent reaction with strain promoted azide-alkyne cycloaddition protocol has been utilized in concert or independently to prepare a small family of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. With sequential
Ching-Hua Tsai +7 more
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Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads [PDF]
ACS Medicinal Chemistry Letters, 2016 The tubulysin class of natural products has attracted much attention from the medicinal chemistry community due to its potent cytotoxicity against a wide range of human cancer cell lines, including significant activity in multidrug-resistant carcinoma models. As a result of their potency, the tubulysins have become an important tool for use in targeted
Carolyn A, Leverett +15 more
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Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences
Exploration of Targeted Anti-tumor Therapy, 2022 Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cytotoxic chemotherapy.
Marilia Barreca +5 more
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Progresses in research and development of antibody-drug conjugate
生物医学转化, 2021 Through referring to the literature and related databases, the research process of antibodyconjugated drugs was reviewed, and the key elements of ADC were summarized.
Wu Gang +6 more
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High-performance payload data handling system for Gaia [PDF]
, 2006 Gaia is the most ambitious space astrometry mission currently envisaged and is a technological challenge in all its aspects. We describe a proposal for the payload data handling system of Gaia, as an example of a high-performance, real-time, concurrent ...
Luri Carrascoso, Xavier +2 more
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Yasir-ali-farrukh/Payload-Byte: V1.0
, 2022 Payload-Byte is a tool for extracting and labeling packet capture (Pcap) files of modern network intrusion detection ...
SyedWaliAbbas +2 more
core +1 more source
Antibody-Drug Conjugates in Solid Tumor Oncology: An Effectiveness Payday with a Targeted Payload
Pharmaceutics, 2023 Antibody–drug conjugates (ADCs) are at the forefront of the drug development revolution occurring in oncology. Formed from three main components—an antibody, a linker molecule, and a cytotoxic agent (“payload”), ADCs have the unique ability to deliver ...
A. Kondrashov +5 more
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Spectrally compact optical subcarrier multiplexing with 42.6 Gbit/s AM-PSK payload and 2.5Gbit/s NRZ labels [PDF]
, 2006 A novel approach to optical subcarrier multiplexing with compact spectrum is demonstrated using a 42.6 Gbit/s AM-PSK payload and 2.5 Gbit/s NRZ label. In this implementation, the payload introduces a 4.8 dB penalty on the label receiver sensitivity, and ...
Barry, Liam P. +5 more
core +2 more sources
PLoS ONE, 2023 Subsets of tumor-produced cell surface and secreted proteins can bind to IgG1 type antibodies and suppress their immune-effector activities. As they affect antibody and complement-mediated immunity, we call these proteins humoral immuno-oncology (HIO ...
N. Nicolaides, J. Kline, L. Grasso
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