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Cytotoxic T cells and mycobacteria [PDF]
FEMS Microbiology Letters, 2001 How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
Célio Lopes Silva +7 more
openaire +3 more sources
Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. [PDF]
PLoS ONE, 2013 Existing approaches that quantify cytotoxic T cell responses rely on bulk or surrogate measurements which impede the direct identification of single activated T cells of interest.
Thomas A Zangle +4 more
doaj +1 more source
Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
mBio, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier +19 more
doaj +1 more source
The Expanding Arsenal of Cytotoxic T Cells
Frontiers in Immunology, 2022 Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they mobilise their killing machinery that is released into the synaptic cleft to orchestrate the demise
Cassioli, Chiara, Baldari, Cosima T
openaire +5 more sources
In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]
PLoS Pathogens, 2010 The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong +9 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Objectives: Evaluation of the feasibility of SARS-CoV-2-specific T cell manufacturing for adoptive T cell transfer in COVID-19 patients at risk to develop severe disease.Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of ...
Agnes Bonifacius +28 more
doaj +1 more source
The Era of Cytotoxic CD4 T Cells
Frontiers in Immunology, 2022 In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades, our understanding of CD4 T cell differentiation has expanded and the initial paradigm of a dichotomic CD4 T cell family has been revisited to accommodate a ...
Mara Cenerenti +7 more
openaire +4 more sources
Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. [PDF]
PLoS ONE, 2010 BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response.
Jelle de Wit +6 more
doaj +1 more source
Cell Death and Disease, 2020 Glioblastoma multiforme (GBM) is highly invasive, with a high recurrence rate and limited treatment options, and is the deadliest glioma. Exosomes (Exos) have attracted much attention in the diagnosis and treatment of GBM and are expected to address the ...
Ming Wang +5 more
semanticscholar +1 more source
Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells
Frontiers in Immunology, 2022 T cell receptor-engineered T cells (TCR-Ts) have emerged as potent cancer immunotherapies. While most research focused on classical cytotoxic CD8+ T cells, the application of CD4+ T cells in adoptive T cell therapy has gained much interest recently ...
Yanling Liang +17 more
doaj +1 more source