Results 21 to 30 of about 2,716,407 (409)

A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. [PDF]

PLoS ONE, 2012
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing.
Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F Huang   +5 more
doaj   +1 more source

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation

Frontiers in Immunology, 2022
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients treated ...
Emily J. Lelliott, Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Mark R. Dowling, Carolyn Shembrey, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Conor J. Kearney, Jessica Michie, Ian A. Parish, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Amelia J. Brennan, Jane Oliaro, Jane Oliaro   +20 more
doaj   +1 more source

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]

, 2014
Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P, Effros, Rita B, Koduri, Megha P, Ramirez, Christina M, Ryba, Danielle M   +4 more
core   +6 more sources

CD8⁺ T Cells in Atherosclerosis

Cells, 2020
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
doaj   +1 more source

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules [PDF]

, 1991
THE α1 and α2 domains of major histocompatibility complex (MHC) class I molecules function in the binding and presentation of foreign peptides to the T-cell antigen receptor and control both negative and positive selection of the T-cell repertoire ...
AM Norment, Carla J. Aldrich, CJ Aldrich, CJ Aldrich, HR MacDonald, HS Teh, HS Teh, HS Teh, IA Stroynowski, IS Trowbridge, Iwona Stroynowski, J Sprent, James Forman, JC Zuniga-Pflucker, JM Connolly, Lee Hood, M Reddehase, MA Alexander, PJ Bjorkman, R Salter, RC Budd, Robert E. Hammer, RR Zamoyska, S Marusic-Galesic, S Qin, Sharon Jones-Youngblood, UH Koszinowski, Ulrich Koszinowski, W-P Fung-Leung, WR Lie, WR Lie   +30 more
core   +1 more source

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size [PDF]

, 2016
Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging.
A Harari, A Lelic, AM Simanek, AR Hersperger, AW Sylwester, C Courivaud, C Riou, E Derhovanessian, E Gimenez, E Sinclair, EJ Wherry, ET Roberts, F Bihl, F Kern, F Sallusto, G Makedonas, G Makedonas, G Pawelec, G Pawelec, GC Wang, GC Wang, IG Rodrigue-Gervais, J Cheng, J van Zanten, JM Fletcher, L Cicin-Sain, L Cicin-Sain, L Krol, ML Pita-Lopez, MR Betts, MR Wills, N Khan, P Trzonkowski, PA Darrah, Q Ouyang, R Lachmann, R Solana, R Vescovini, RA Seder, RA van Lier, S Cantisan, SA Migueles, SH Park, SR Hadrup, T Crough, V Appay, YL Chiu, YN Ji   +47 more
core   +1 more source

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
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The role of cytotoxic T cells [PDF]

Retrovirology, 2010
The development of anti-HIV T cell-based vaccines is a current major objective in the strategy to halt AIDS pandemic. For this purpose the understanding of the mechanisms underlying effective HIV-specific CD8+ T cell responses is of great importance. One of the most appealing models for such efficient responses is found today in HIV controllers (HICs),
openaire   +3 more sources

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

In-vivo gp100-specific Cytotoxic CD8+ T Cell Killing Assay

Bio-Protocol, 2018
Cytotoxic CD8+ T lymphocytes (CTLs) represent a crucial component of the adaptive immune system and play a prominent role in the anti-tumor immune responses of both mice and humans.
Mahdia Benkhoucha, Nicolas Molnarfi, Elodie Belnoue, Madiha Derouazi, Patrice Lalive   +4 more
doaj   +1 more source