Results 11 to 20 of about 518,936 (262)

In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. [PDF]

PLoS Pathogens, 2010
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms.
Joseph K Wong, Matthew C Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C Ignacio, Theresa Russell, Satish K Pillai, David J Looney, Satya Dandekar   +9 more
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Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy

Frontiers in Bioengineering and Biotechnology, 2022
Objectives: Evaluation of the feasibility of SARS-CoV-2-specific T cell manufacturing for adoptive T cell transfer in COVID-19 patients at risk to develop severe disease.Methods: Antiviral SARS-CoV-2-specific T cells were detected in blood of ...
Agnes Bonifacius, Sabine Tischer-Zimmermann, Maria Michela Santamorena, Philip Mausberg, Josephine Schenk, Stephanie Koch, Johanna Barnstorf-Brandes, Nina Gödecke, Jörg Martens, Lilia Goudeva, Murielle Verboom, Jana Wittig, Jana Wittig, Britta Maecker-Kolhoff, Herrad Baurmann, Caren Clark, Olaf Brauns, Martina Simon, Peter Lang, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Oliver A. Cornely, Michael Hallek, Rainer Blasczyk, Dominic Seiferling, Philipp Köhler, Philipp Köhler, Britta Eiz-Vesper   +28 more
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Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. [PDF]

PLoS ONE, 2010
BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response.
Jelle de Wit, Yuri Souwer, Tineke Jorritsma, Hanny Klaasse Bos, Anja ten Brinke, Jacques Neefjes, S Marieke van Ham   +6 more
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Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells

Frontiers in Immunology, 2022
T cell receptor-engineered T cells (TCR-Ts) have emerged as potent cancer immunotherapies. While most research focused on classical cytotoxic CD8+ T cells, the application of CD4+ T cells in adoptive T cell therapy has gained much interest recently ...
Yanling Liang, Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Hai-Xi Sun, Hai-Xi Sun, Linnan Zhu, Linnan Zhu, Linnan Zhu   +17 more
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Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

eLife, 2020
Understanding T cell function in vivo is of key importance for basic and translational immunology alike. To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of granzyme B, a key component of cytotoxic ...
Praneeth Chitirala, Hsin-Fang Chang, Paloma Martzloff, Christiane Harenberg, Keerthana Ravichandran, Midhat H Abdulreda, Per-Olof Berggren, Elmar Krause, Claudia Schirra, Trese Leinders-Zufall, Fritz Benseler, Nils Brose, Jens Rettig   +12 more
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A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. [PDF]

PLoS ONE, 2012
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing.
Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F Huang   +5 more
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NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation

Frontiers in Immunology, 2022
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients treated ...
Emily J. Lelliott, Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Mark R. Dowling, Carolyn Shembrey, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Conor J. Kearney, Jessica Michie, Ian A. Parish, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Amelia J. Brennan, Jane Oliaro, Jane Oliaro   +20 more
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CD8⁺ T Cells in Atherosclerosis

Cells, 2020
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
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In-vivo gp100-specific Cytotoxic CD8+ T Cell Killing Assay

Bio-Protocol, 2018
Cytotoxic CD8+ T lymphocytes (CTLs) represent a crucial component of the adaptive immune system and play a prominent role in the anti-tumor immune responses of both mice and humans.
Mahdia Benkhoucha, Nicolas Molnarfi, Elodie Belnoue, Madiha Derouazi, Patrice Lalive   +4 more
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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

Cell Reports, 2020
Summary: Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely ...
Eri Katsuyama, Abel Suarez-Fueyo, Sean J. Bradley, Masayuki Mizui, Ana V. Marin, Lama Mulki, Suzanne Krishfield, Fabio Malavasi, Joon Yoon, Shannan J. Ho Sui, Vasileios C. Kyttaris, George C. Tsokos   +11 more
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