Results 21 to 30 of about 518,936 (262)

Cytotoxic Efficiency of Human CD8+ T Cell Memory Subtypes

Frontiers in Immunology, 2022
Immunological memory is important to protect humans against recurring diseases. Memory CD8+ T cells are required for quick expansion into effector cells but also provide immediate cytotoxicity against their targets. Whereas many functions of the two main
Arne Knörck, Gertrud Schäfer, Dalia Alansary, Josephine Richter, Lorenz Thurner, Markus Hoth, Eva C. Schwarz   +6 more
doaj   +1 more source

Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8+ T lymphocytes against Leishmania major [PDF]

BioImpacts, 2023
Introduction: Induction of a protective immune response against Leishmania major requires the activation of both TH1 and CD8+ T lymphocytes. Because L. major is an intra-phagosomal parasite, its antigens do not have access to MHC-I.
Fatemeh Beyzay, Ahamad Zavaran Hosseini, Ali Hazrati, Mozhdeh Karimi, Sara Soudi   +4 more
doaj   +1 more source

The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma

Frontiers in Medicine, 2023
ObjectivesIn malignant tumors, elevated infiltration of intratumoral CD8+ cytotoxic T cells predicts a beneficial prognosis, whereas high levels of CD15+ neutrophils in peritumor tissues indicate poor prognosis.
Juanjuan Song, Jialing Wu, Jiaxuan Ding, Yangxin Liang, Changlong Chen, Yimin Liu   +5 more
doaj   +1 more source

The Expanding Arsenal of Cytotoxic T Cells

Frontiers in Immunology, 2022
Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they mobilise their killing machinery that is released into the synaptic cleft to orchestrate the demise
Cassioli, Chiara, Baldari, Cosima T
openaire   +5 more sources

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Comparisons of serum CTLA-4 levels between treated and Untreated SCLC and NSCLC Patients

مجلة كلية الطب
Background: Small cell lung cancer and non-small cell lung cancer are the two main types of lung cancer and major causes of cancer-related death worldwide. Objectives: To compare serum cytotoxic T-lymphocyte-associated antigen 4 levels between treated
Zinah Al-Hayali, Rasha Al-Humairi
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells

EMBO Reports
Memory-like or precursor exhausted (Tpex) CD8+ T cells are a critical reservoir in chronic infections and cancer, yet the signals sustaining their cytokine production remain unclear.
Matthias Barone, Stefan Peidli, Anika Neuschulz, Karla Riesterer, Christina Iwert, Laia Junquera, Somesh Sai, Olufemi Bolaji, Diana Bakoueva, Christine Appelt, Benedikt Obermayer, Bertram Klinger, Alexandra Trinks, Anja Sieber, Nils Blüthgen, Birgit Sawitzki   +15 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source