Results 51 to 60 of about 2,869,113 (404)

TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]

, 2018
A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L, Chen, Yvonne Y, Hou, Andrew J, Lorenzini, Michael H, Zah, Eugenia   +4 more
core   +1 more source

T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression.

Journal of Clinical Oncology, 2016
Purpose Peripheral blood-derived antigen-specific cytotoxic T cells (CTLs) provide a readily available source of effector cells that can be administered with minimal toxicity in an outpatient setting.
A. Chapuis, Ilana M. Roberts, John A Thompson, K. Margolin, S. Bhatia, Sylvia M. Lee, H. Sloan, Ivy P. Lai, Erik A. Farrar, F. Wagener, Kendall C. Shibuya, Jianhong Cao, J. Wolchok, P. Greenberg, C. Yee   +14 more
semanticscholar   +1 more source

EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4 + T cells in chronic lymphocytic leukemia [PDF]

, 2021
The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in CD4(+) T cells, which has been linked to immunosuppressive and cytotoxic activities.
Arnold, Sebastian J., Arseni, Lavinia, Bordas, Marie, Colomer, Dolors, Dietrich, Sascha, Gaupel, Ann-Christin, Izcue, Ana, Kilpert, Fabian, Krötschel, Marit, Lichter, Peter, Llaó Cid, Laura, Lupar, Ekaterina, Roessner, Philipp M, Roider, Tobias, SCHIFFLERS, Christoph, Seiffert, Martina, Sellner, Leopold, Stilgenbauer, Stephan   +17 more
core   +2 more sources

Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial.

Blood, 2007
We present the results of a multicenter clinical trial using Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) generated from EBV-seropositive blood donors to treat patients with EBV-positive posttransplantation lymphoproliferative disease
T. Haque, G. Wilkie, Marie M. Jones, C. Higgins, G. Urquhart, P. Wingate, D. Burns, K. McAulay, M. Turner, C. Bellamy, P. Amlot, D. Kelly, A. Macgilchrist, M. Gandhi, A. Swerdlow, D. Crawford   +15 more
semanticscholar   +1 more source

Next-Generation Immunotherapies to Improve Anticancer Immunity

Frontiers in Pharmacology, 2021
Checkpoint inhibitors are widely used immunotherapies for advanced cancer. Nonetheless, checkpoint inhibitors have a relatively low response rate, work in a limited range of cancers, and have some unignorable side effects.
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee, Cara Haymaker   +5 more
doaj   +1 more source

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

Journal of Immunology, 1994
The relationship between binding affinity for HLA class I molecules and immunogenicity of discrete peptide epitopes has been analyzed in two different experimental approaches. In the first approach, the immunogenicity of potential epitopes ranging in MHC
A. Sette, A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. Kast, C. Melief, C. Oseroff, L. Yuan, J. Ruppert, J. Sidney, M. D. Guercio, S. Southwood, R. Kubo, R. Chesnut, H. Grey, F. Chisari   +16 more
semanticscholar   +1 more source

UVB radiation induced effects on cells studied by FTIR spectroscopy [PDF]

European Biophysics Journal Volume 39, Number 6 / May, 2010, 2010
We have made a preliminary analysis of the results about the eVects on tumoral cell line (lymphoid T cell line Jurkat) induced by UVB radiation (dose of 310 mJ/cm^2) with and without a vegetable mixture. In the present study, we have used two techniques: Fourier transform infrared spectroscopy (FTIR) and flow cytometry.
arxiv   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.

Blood, 2013
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α(+)DC are specialized to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity.
G. Nizzoli, Jana Krietsch, Anja Weick, S. Steinfelder, F. Facciotti, P. Gruarin, Annalisa Bianco, B. Steckel, M. Moro, M. Crosti, C. Romagnani, K. Stölzel, S. Torretta, L. Pignataro, C. Scheibenbogen, P. Neddermann, R. de Francesco, S. Abrignani, J. Geginat   +18 more
semanticscholar   +1 more source