Results 61 to 70 of about 831,286 (305)

In vivo OVA-specific Cytotoxic CD8+ T Cell Killing Assay

Bio-Protocol, 2016
Cytotoxic CD8+ T cells are responsible for the lysis of cells expressing peptides associated with MHC class I molecules and derived from infection with a pathogen or from mutated antigens.
Nada Chaoul, Catherine Fayolle, Claude Leclerc   +2 more
doaj   +1 more source

Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer

JCI Insight, 2022
Clinical outcomes in colorectal cancer (CRC) correlate with T cell infiltrates, but the specific contributions of heterogenous T cell types remain unclear.
Kazuya Masuda, Adam Kornberg, Jonathan Miller, Sijie Lin, Nathan Suek, Theo Botella, Kerim A. Secener, Alyssa M. Bacarella, Liang Cheng, Matthew Ingham, Vilma Rosario, Ahmed M. Al-Mazrou, Steven A. Lee-Kong, Ravi P. Kiran, Marlon Stoeckius, Peter Smibert, Armando Del Portillo, Paul E. Oberstein, Peter A. Sims, Kelley S. Yan, Arnold Han   +20 more
doaj   +1 more source

Immune dysregulation in immunoglobulin G4–related disease

Japanese Dental Science Review, 2023
(IgG4-RD) is an immune-mediated fibrotic disorder characterized by severe resolution of inflammation and dysregulation of wound healing. IgG4-RD has been considered a unique disease since 2003, and significant progress has been achieved in the ...
Takashi Maehara, Risako Koga, Seiji Nakamura   +2 more
doaj   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Carbohydrate moieties of major histocompatibility complex class I alloantigens are not required for their recognition by T lymphocytes. [PDF]

, 1985
The ability to generate specific cytotoxic responses using purified major histocompatibility complex (MHC) antigen in liposomes has made it possible to directly assess the importance of class I carbohydrate moieties in T cell recognition of alloantigen ...
Goldstein, SA, Mescher, MF
core  

Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]

, 1994
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson, Anderson, Bernot, Bucy, Bucy, Chan, Char, Chen, Chen, Chen, Chen, Chomczynski, Ciccone, Cihak, Coltey, Cooper, Dennert, Guillemot, Göbel, Hori, Hála, Laemmli, Lahti, Lanier, Lanier, Lillehoj, Mingari, Moretta, Myers, Nowak, Ortaldo, Phillips, Phillips, Poggi, Ratcliffe, Ritz, Rodewald, Schauenstein, Schnetzler, Sharma, Sowder, Spurr, Suzuki, Terry, Tjoelker, Trinchieri, Voss, Vujanovic, Wilson   +48 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

MULTICOLOR FLOW CYTOMETRIC ANALYSIS OF CYTOTOXIC T CELL SUBSETS

Медицинская иммунология, 2016
Multiparameteric flow analysis has offered an ability of simultaneous analysis of multiple molecules at the single-cell level. Peripheral blood cells from 110 healthy subjects aged 18-65 years (59 males and 51 females) were stained with antibodies to CD3,
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebryakova   +4 more
doaj   +1 more source

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

Acta Neuropathologica Communications, 2023
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with ...
Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau   +30 more
doaj   +1 more source