Results 71 to 80 of about 2,670,296 (390)
In vivo OVA-specific Cytotoxic CD8+ T Cell Killing Assay
Bio-Protocol, 2016 Cytotoxic CD8+ T cells are responsible for the lysis of cells expressing peptides associated with MHC class I molecules and derived from infection with a pathogen or from mutated antigens.
Nada Chaoul +2 more
doaj +1 more source
CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. [PDF]
, 1992 Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response.
Azuma, M +4 more
core +1 more source
A combination of soluble helper factors bypasses the requirement for stimulator cells and induces nonspecific cytotoxic T cell responses [PDF]
, 1985 The specificity of cytotoxic T lymphocyte (CTL) responses generated in the presence of lymphokines was studied. Thymic responder cells were activated in the presence of stimulator cells that differed in their metabolic activity.
Dröge, W., Falk, Werner, Männel, D. N.
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
OncoImmunology, 2018 Toll-Like Receptor 9 (TLR9) stimulation selectively triggers the formation of a cell cluster termed intrahepatic myeloid aggregation for T cell expansion” (iMATE) in a mouse chronic viral hepatitis model.
Yung-Chang Lin +12 more
doaj +1 more source
MULTICOLOR FLOW CYTOMETRIC ANALYSIS OF CYTOTOXIC T CELL SUBSETS
Медицинская иммунология, 2016 Multiparameteric flow analysis has offered an ability of simultaneous analysis of multiple molecules at the single-cell level. Peripheral blood cells from 110 healthy subjects aged 18-65 years (59 males and 51 females) were stained with antibodies to CD3,
I. V. Kudryavtsev +4 more
doaj +1 more source
Haematologica, 2020 Peripheral T-cell lymphoma comprises a heterogeneous group of mature non-Hodgkin lymphomas. Their diagnosis is challenging, with up to 30% of cases remaining unclassifiable and referred to as “not otherwise specified”.
Fanny Drieux +25 more
doaj +1 more source
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism [PDF]
, 2011 SummaryIn cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL
Ahmed +58 more
core +3 more sources
Breast Cancer Research, 2014 The infiltration of FOXP3+ regulatory T cells into invasive tumors has been reported to be associated with survival in a variety of cancers. The prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in breast cancer, however, remains ...
Shuzhen Liu +6 more
semanticscholar +1 more source
Macrophages as Cytotoxic Effector Cells
Immunobiology, 1982 Cells of the mononuclear phagocyte system can be activated by lymphokines to both increased extracellular cytotoxicity against tumor targets and intracellular cytotoxicity against micro-organisms. In addition, these effector cells can kill antibody-coated target cells in an ADCC system.
D. Sun +2 more
openaire +3 more sources