Results 201 to 210 of about 15,530,977 (295)

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Tebentafusp elicits on-target cutaneous immune responses driven by cytotoxic T cells in uveal melanoma patients. [PDF]

J Clin Invest
Staeger R, Tastanova A, Ghosh A, Winkelbeiner N, Shukla P, Kolm I, Turko P, Benlahrech A, Harper J, Broomfield A, Camera A, Ambrosio M, Haunerdinger V, Cheng PF, Ramelyte E, Pham J, Kreutmair S, Becher B, Levesque MP, Dummer R, Meier-Schiesser B.   +20 more
europepmc   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable <i>in vitro</i> model of exhaustion. [PDF]

Immunother Adv
Alsubaiti A, Alamir H, Huynh L, Grant T, Aljohani A, Chou PH, Shi Y, Alismail M, Mason LR, Herman A, Bridgeman JS, Holland CJ, Wülfing C.   +12 more
europepmc   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source

Required minimal protein domain of flower for synaptobrevin2 endocytosis in cytotoxic T cells. [PDF]

Cell Mol Life Sci
Ravichandran K, Schirra C, Urbansky K, Tu SM, Alawar N, Mannebach S, Krause E, Stevens D, Lancaster CRD, Flockerzi V, Rettig J, Chang HF, Becherer U.   +12 more
europepmc   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source

Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant. [PDF]

Front Immunol
Chang CC, Liu YN, Xu Z, Vasilescu ER, Li P, Ho EK, Li M, Husain SA, Bhagat G, Mohan S, Vlad G, Suciu-Foca N.   +11 more
europepmc   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source

GZM^hi Cytotoxic T Cells: A Key Discovery in Fibrotic Hypersensitivity Pneumonitis. [PDF]

Am J Respir Crit Care Med
Karampitsakos T, Herazo-Maya JD.
europepmc   +1 more source