Results 1 to 10 of about 408,968 (233)
Healthy aging—would cytotoxic T lymphocytes stand out? [PDF]
Cell Death Discovery, 2023 Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders.
Tianyu Zhang, Jinjin Zhang, Shixuan Wang
doaj +2 more sources
Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation [PDF]
Transplant InternationalXenotransplantation represents a potential solution to the shortage of organs for transplantation. The recent advancements in porcine genetic modification have addressed hyperacute and acute vascular rejection; however, challenges persist with regard to ...
Viktoriia Galdina +2 more
doaj +2 more sources
Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses [PDF]
Frontiers in Immunology, 2022 miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses—a hallmark of natural HIV control— by miRNA modulation in T cells.
Nadia Madrid-Elena +23 more
doaj +2 more sources
Rapamycin improves Graves’ orbitopathy by suppressing CD4+ cytotoxic T lymphocytes [PDF]
JCI Insight, 2023 CD4+ cytotoxic T lymphocytes (CTLs) were recently implicated in immune-mediated inflammation and fibrosis progression of Graves’ orbitopathy (GO). However, little is known about therapeutic targeting of CD4+ CTLs.
Meng Zhang +13 more
doaj +2 more sources
Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes. [PDF]
Proceedings of the National Academy of Sciences, 1987 To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal
David M. Kranz, Herman N. Eisen
openaire +3 more sources
Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia
Studia Medyczne, 2021 Several clinical reports have demonstrated a spectrum of neurological manifestations of COVID-19 patients with subsequent post-mortem neuropathological findings. The aim of the case description is to show spotty inflammatory lesions in the olfactory bulb,
Marcin Zaremba +2 more
doaj +1 more source
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2021 Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu +19 more
openaire +6 more sources
Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes
Frontiers in Immunology, 2020 Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in
Marwa Sleiman +3 more
doaj +1 more source
Медицинская иммунология, 2020 We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry.
O. V. Makarova +3 more
doaj +1 more source
Сибирский онкологический журнал, 2023 Purpose of the study: development of in vitro laboratory models to evaluate quality parameters and specific efficacy of dendritic cell vaccine (DCV).Material and Methods.
T. L. Nekhaeva +8 more
doaj +1 more source