Results 11 to 20 of about 11,464,920 (290)

IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy [PDF]

Signal Transduction and Targeted Therapy
Silvia Dusi, Vincenzo Bronte, Francesco De Sanctis   +2 more
doaj   +2 more sources

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes. [PDF]

Proceedings of the National Academy of Sciences, 1987
To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal
D M, Kranz, H N, Eisen
openaire   +2 more sources

Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia

Studia Medyczne, 2021
Several clinical reports have demonstrated a spectrum of neurological manifestations of COVID-19 patients with subsequent post-mortem neuropathological findings. The aim of the case description is to show spotty inflammatory lesions in the olfactory bulb,
Marcin Zaremba, Agnieszka Płusa, Agnieszka Radowicz-Chil   +2 more
doaj   +1 more source

Production of CD87 Antigen-Specific CAR-T Lymphocytes and Assessment of Their In Vitro Functional Activity

Клиническая онкогематология, 2022
Aim. To generate anti-CD87 CAR-T lymphocytes and to assess their in vitro functional activity. Materials & Methods. Т-lymphocytes isolated from healthy donor peripheral blood were transduced with the anti-CD87-CAR, T2A, and FusionRed gene coding ...
M. V. Neklesova, Sergei Vladimirovich Smirnov, A. A. Shatilova, K. A. Levchuk, A. E. Ershova, S. A. Silonov   +5 more
doaj   +1 more source

Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes

Frontiers in Immunology, 2020
Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in
Marwa Sleiman, David R. Stevens, Praneeth Chitirala, Jens Rettig   +3 more
doaj   +1 more source

Sex differences of subpopulation composition of lymphocytes in the peripheral blood in experimental acute and chronic ulcerative colitis

Медицинская иммунология, 2020
We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry.
O. V. Makarova, E. A. Postovalova, Yu. Gao, M. T. Dobrynina   +3 more
doaj   +1 more source

ANTI-APOPTOTIC EFFECT OF CD95 RECEPTOR IN NA VE CD8+ T-LYMPHOCYTES IN CHILDREN WITH ACUTE INFECTIOUS MONONUCLEOSIS

Инфекция и иммунитет, 2016
Acute infectious mononucleosis is a widespread viral disease, which most often manifests in childhood. The development of acute infectious mononucleosis is accompanied by the change of the CD4+/CD8+ T-lymphocytes ratio and the increase of the virus ...
E. N. Filatova, E. V. Anisenkova, N. B. Presnyakova, T. D. Sycheva, E. A. Kulova, O. V. Utkin   +5 more
doaj   +1 more source

Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine

Сибирский онкологический журнал, 2023
Purpose of the study: development of in vitro laboratory models to evaluate quality parameters and specific efficacy of dendritic cell vaccine (DCV).Material and Methods.
T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva   +8 more
doaj   +1 more source

Features of the immune status of patients with acute coronary syndrome who underwent СOVID-19, depending on the number of cytotoxic T lymphocytes (CD8⁺)

Медицинская иммунология, 2023
The 2019 coronavirus disease (COVID-19) pandemic has had an unprecedented impact on health and economies around the world. Direct myocardial injury and cytokine storm, leading to destabilization of preexisting plaques and accelerated formation of new ...
E. A. Safronova, L. V. Ryabova, A. V. Zurochka   +2 more
doaj   +1 more source

Peripheral blood lymphocyte subtypes in dogs with different stages of myxomatous mitral valve disease

Journal of Veterinary Internal Medicine, 2021
Background Data on alterations in peripheral blood lymphocyte (PBL) subtypes in dogs with myxomatous mitral valve disease (MMVD) is lacking. Objectives To investigate PBL subtypes and their correlation with parameters of inflammation and MMVD progression
Natalia Druzhaeva, Alenka Nemec Svete, Alojz Ihan, Katka Pohar, Aleksandra Domanjko Petrič   +4 more
doaj   +1 more source