Results 171 to 180 of about 30,582 (245)
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma+14 more
wiley +1 more source
NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment. [PDF]
Turiello R+14 more
europepmc +1 more source
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao+9 more
wiley +1 more source
Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis+7 more
wiley +1 more source
Does a natural killer need a CAR? [PDF]
Wang K, Zhang Y, Han Z, Wang Y.
europepmc +1 more source
A multifunctional anisotropic Au‐Pd heterostructured nanosystem is developed that incorporates a plasmonically enhanced Au‐Pd core, with a shell composed of a biodegradable, Mn‐doped targeting peptide. The nanosystem integrates photothermal, radiotherapeutic, and immunomodulatory functions.
Cheng Chen+8 more
wiley +1 more source
NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells. [PDF]
Marangio C+9 more
europepmc +1 more source
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han+16 more
wiley +1 more source
Generating tumor-specific T cells based on a head and neck cancer organoid for adoptive cell therapy. [PDF]
Chen Y+6 more
europepmc +1 more source
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui+6 more
wiley +1 more source