Results 171 to 180 of about 30,319 (222)

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

Expanding role of antibodies in kidney transplantation.

World J Transplant
Abbas K, Mubarak M.
europepmc   +1 more source

Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs. [PDF]

Cells
Kaur K, Celis AP, Jewett A.
europepmc   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer. [PDF]

Cancer Immunol Res
Schwarz E, Savardekar H, Zelinskas S, Mouse A, Lapurga G, Lyberger J, Rivaldi A, Ringwalt EM, Miller KE, Yu L, Behbehani GK, Cripe TP, Carson WE.   +12 more
europepmc   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Short-term oral zinc supplementation enhances Natural Killer cell functionality and decreases circulating Innate Lymphoid Cell counts and frequencies in healthy young adults. [PDF]

J Transl Med
Amling L, Rink L, Bennstein SB.
europepmc   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

NK Count and Natural Cytotoxicity in Immune Nonresponders Versus Responders Living With HIV. [PDF]

J Med Virol
Silvestre C, Tuaillon E, Duroyon MM, Abrantes M, Thibout JC, Villalba M, Picot MC, Gross A, Makinson A.   +8 more
europepmc   +1 more source

Are PM6:Y6 Bulk Heterojunction Photoactive Films Cytocompatible and Electrically Stable in Biological Environments?

Advanced Electronic Materials, EarlyView.
PM6:Y6 organic photovoltaic films are systematically studied to understand their potential for use in bioelectronics. The films exhibit excellent stability in simulated physiological environments, enabling consistent power delivery and demonstrating compatibility with rat neurons and the choriallantoic membrane of chicken embryos.
Mathias Polz, Konrad Binter, Kaila M. Yallum, Thomas Rath, Marta Nowakowska‐Desplantes, Christa Schimpel, Gerhard Sommer, Nassim Ghaffari‐Tabrizi‐Wizsy, Natalie Banerji, Gregor Trimmel, Theresa Rienmüller   +10 more
wiley   +1 more source