Results 131 to 140 of about 1,197,953 (344)

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

open access: gold, 2014
Jan P. Böttcher   +10 more
openalex   +1 more source

Cytotoxic Alkaloids from Leaves and Twigs of Dasymaschalon sootepense [PDF]

open access: bronze, 2014
Sakchai Hongthong   +6 more
openalex   +1 more source

cytotoxic

open access: yes
Citation: 'cytotoxic' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13071 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery

open access: yesInternational Journal of Nanomedicine, 2016
Xiwei Yu,1 Jiahui Hou,1 Yijie Shi,1 Chang Su,2 Liang Zhao1 1School of Pharmacy, 2School of Veterinary Medicine, Jinzhou Medical University, Jinzhou, People’s Republic of China Abstract: It is well known that most anticancer drugs commonly show ...
Yu X, Hou J, Shi Y, Su C, Zhao L
doaj  

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

open access: yesFEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili   +2 more
wiley   +1 more source

Investigation of antioxidant, cytotoxic, tyrosinase inhibitory activities, and phenolic profiles of green, white, and black teas

open access: gold, 2019
Nuriye Korkmaz   +7 more
openalex   +1 more source

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