Results 231 to 240 of about 686,731 (316)

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li   +9 more
wiley   +1 more source

Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X‐ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights ...
Rosalía López‐Méndez   +11 more
wiley   +1 more source

In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
In situ‐gelling poly(oligoethylene glycol methacrylate) (POEGMA)‐based hydrogels exhibit broad‐spectrum antibacterial activity against both gram‐positive and gram‐negative bacteria based on the dual covalent attachment of quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP) into the hydrogel networks, enabling effective in vivo burn ...
Fei Xu   +8 more
wiley   +1 more source

Living Microalgae‐Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
A magnetic microrobot fabricated by Spirulina platensis is proposed to accumulate in tumor regions and generate in situ high calcium concentration and sufficient oxygen. These characteristics of the microrobot present a strategy for triggering calcium overload therapy and chlorophyll‐mediated photodynamic therapy, and such combination resulted in a ...
Shuai Jiang   +12 more
wiley   +1 more source

An In Situ Curing, Shear‐Responsive Biomaterial Designed for Durable Embolization of Microvasculature

open access: yesAdvanced Healthcare Materials, EarlyView.
NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham   +16 more
wiley   +1 more source

Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof‐of‐Concept Study

open access: yesAdvanced Healthcare Materials, EarlyView.
Helicobacter pylori gastric infection is widespread and recurrency is common, fuelled by bacterial resistance to antibiotics. Therefore, specific and noninducing resistance alternative treatments are an urgent need. Taking advantage of this gastric pathogen auxotrophy for cholesterol, a “trojan horse” strategy for H.
Ana Sofia Pinho   +6 more
wiley   +1 more source

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