Results 261 to 270 of about 1,629,625 (355)

Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks

Advanced Functional Materials, EarlyView.
Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert, Daniel Fougnier, Bo Van Durme, Jenna Grutzmacher, Ryan Clarke, Susan Cao, Zhenghao Li, Ujjwal Aryal, Jason A. Horton, Sandra Van Vlierberghe, Pranav Soman   +10 more
wiley   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Anti-Cancer Effect of a New 5-FU Derivative Containing Triazole-Bearing Mannose (5-FUD-MAN) Against Human Breast Cancer Cells Through LC3B-Mediated Cell Death. [PDF]

J Biochem Mol Toxicol
Şanci E, Aliyeva A, Bakan B, Özkaraca M, Halay E, Ay K, Karayildirim T, Karabay Yavasoglu NU.   +7 more
europepmc   +1 more source

The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease. [PDF]

Hepatol Commun
Li Z, Gong Y, Ye L, Liu W.
europepmc   +1 more source

Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy. [PDF]

Front Immunol
Zhang R, Ma P, Tang K, Cao Y, Yang Y, Hao S, Li T, Peng X.   +7 more
europepmc   +1 more source

Targeting ST3GAL1 to downregulate ligands for the glycoimmune checkpoint Siglec-7 and reverse immune escape in hepatocellular carcinoma. [PDF]

Cancer Immunol Immunother
Fan TC, Hung TH, Yeh CT, Lin PT, Chang NC, Lo TC, Wu TJ, Yu J, Yu AL.   +8 more
europepmc   +1 more source

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson's disease. [PDF]

Cell Death Dis
Ahumada-Montalva P, Muñoz-Carvajal F, Bórquez-Macaya S, Arévalo-Ramírez N, Cisternas-Olmedo M, Jerez C, Urbina-Muñoz V, Gomez W, Urrutia PJ, Hirsch EC, Ahumada M, Barrias P, Muñoz-Yañez C, Herrera-Vásquez A, Arriagada G, Woehlbier U, Calegaro-Nassif M, Sanhueza M, Vidal RL, Rojas-Rivera D.   +19 more
europepmc   +1 more source

Ramantamig (JNJ-79635322), a novel T-cell-engaging trispecific antibody targeting BCMA, GPRC5D, and CD3, in multiple myeloma models.

Blood
Pillarisetti K, Yang D, Luistro L, Yao J, Smith M, Vulfson P, Testa JS, Ponticiello R, Brodeur S, Heidrich B, Packman K, Singh S, Attar R, Elsayed Y, Philippar U.   +14 more
europepmc   +1 more source