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Lymphocyte-Mediated Cytotoxicity
Annual Review of Immunology, 2002Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that ...
John H, Russell, Timothy J, Ley
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Cytotoxic therapy and pregnancy
Pharmacology & Therapeutics, 1997The use of cytotoxic agents during pregnancy may be unavoidable in order to ensure maternal survival-despite the dangers to the developing fetus. We review 217 such cases published between 1983 and 1995, classifying them into 5 groups according to whether the cytotoxic drugs were used to treat leukaemias, malignant lymphomas, severe rheumatic diseases,
U, Ebert, H, Löffler, W, Kirch
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New cytotoxics and non-cytotoxics in epithelial ovarian cancer
International Journal of Gynecological Cancer, 2000Several new cytotoxic agents with activity in relapsed ovarian cancer are being combined with paclitaxel plus platinum as the first step to assess their impact in randomized trials against the standard treatment. These include topotecan, gemcitabine, epirubicin, and liposomal doxorubicin. Because of overlapping toxicities, there have been challenges in
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Cytotoxicity of Methacrylonitrile
Bulletin of Environmental Contamination and Toxicology, 1997V, Vasanthakumari +3 more
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Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell, 2022Philipp Georg +2 more
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