Results 281 to 290 of about 1,019,504 (340)

Kirigami‐Inspired Breathable Smart Contact Lens for Wireless Monitoring of Corneal Hypoxia and Microenvironment

Advanced Healthcare Materials, EarlyView.
A kirigami‐inspired breathable smart contact lens is reported for wireless monitoring of corneal hypoxia and microenvironment. The ultrathin (55 µm) and flexible sensing device enables digitalized, in situ and precise monitoring of dissolved oxygen, humidity, and temperature (R2 >0.98).
Jiaxue Zhu, Ling Yang, Qing Yang, Yin Huang, Yuhang Li, Yueqing He, Xuxu Yang, Zhiyan Yang, Yonghong Jiao, Wenbin Wei, Yihao Chen, Xue Feng   +11 more
wiley   +1 more source

GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout. [PDF]

Cancer Immunol Immunother
Jünemann W, Bley I, Rekowski L, Klokow M, Herppich S, Müller I, Cornils K.   +6 more
europepmc   +1 more source

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim, Ning Guo, Zong Yao Tan, Xing Gao, Pouria Fattahi, Haijiao Liu, Jeehan Chang, Mousa Younesi, Selice Jung, Yewhan Chung, Minkyung Song, Michelle Jung, Dan Dongeun Huh   +12 more
wiley   +1 more source

The Toxicological Profile of Active Pharmaceutical Ingredients-Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications. [PDF]

Pharmaceuticals (Basel)
Muhaimin M, Chaerunisaa AY, Dewi MK, Khatib A, Hazrina A.   +4 more
europepmc   +1 more source

Antioxidant and Anti‐Senescence Polyvinyl Alcohol‐Gallic Acid Supramolecular Hydrogels for Stem Cell Culture

Advanced Healthcare Materials, EarlyView.
The PVA‐GA hydrogel is formed through hydrogen bonding between PVA hydroxyl groups and GA galloyl units, enabling sustainable GA release and its extended biological activity. The hydrogel scavenges ROS to reduce oxidative stress, preventing mitochondrial damage from excessive ROS, mitigating hADSC senescence, and preserving VEGF secretion, offering a ...
Yiduo Zhou, Matías L. Picchio, Yan Nie, Lei Wang, Oihane Sanz, Yue Liu, Xun Xu, Lukas Prantl, Oliver Felthaus, Weiwei Wang, Marcelo Calderón, Nan Ma   +11 more
wiley   +1 more source

Design of a prodrug bispecific antibody masked by a functional molecule for lymphocyte activation for cancer therapy. [PDF]

J Biol Eng
Miura D, Kato Y, Yasunaga M, Kumagai I, Asano R.   +4 more
europepmc   +1 more source

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel, Henning De May, Lauren Anderson, Lorél Y. Medina, Ellie Kennedy, Erica Flores, John O'Rourke, Marian Olewine, Irina Lagutina, Lillian Fitzpatrick, Fred Shultz, Donna F. Kusewitt, Eric Bartee, Sarah Adams, Achraf Noureddine, Rita E. Serda   +15 more
wiley   +1 more source

A lymphostatin homologue from <i>Chlamydia pecorum</i> inhibits mitogen-activated bovine T cell proliferation and IFNγ production. [PDF]

Virulence
Blackburn EA, Chintoan-Uta C, Bease AG, Tuijtel MW, Hateley M, Wear M, Longbottom D, Cassady-Cain R, Stevens MP.   +8 more
europepmc   +1 more source

Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Jonathan J. Chang, Kelsey Brew, Jamie A.G. Hamilton, Varun Kumar, José A. Diaz, Shuichi Takayama   +5 more
wiley   +1 more source

RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity. [PDF]

J Immunother Cancer
Guo H, Hu J, Wang Z, Xu F, Liu Y, Cui L, Zhang H, Xie C, Yao R, Jin H, Guo Z, Wang T, Li L, Lin Y, Wang X, Li H, Xia X.   +16 more
europepmc   +1 more source