Results 31 to 40 of about 370,225 (281)
PLoS ONE, 2017 The role of natural killer (NK) cell function in HIV disease especially in the setting of long-term antiretroviral therapy (ART) and viral suppression is not fully understood.
Zhenwu Luo +9 more
semanticscholar +1 more source
Journal of Pancreatology, 2020 Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate and is notoriously refractory to multiple cancer treatments. In recent years, cancer therapy has expanded beyond traditional cytotoxic chemotherapy to targeted agents and immunotherapy ...
D. Siolas +2 more
semanticscholar +1 more source
Neoplasia: An International Journal for Oncology Research, 2000 Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains.
C.O. Yun +4 more
doaj +1 more source
Bayesian Models and Decision Algorithms for Complex Early Phase Clinical Trials [PDF]
Statistical Science 2010, Vol. 25, No. 2, 227-244, 2010 An early phase clinical trial is the first step in evaluating the effects in humans of a potential new anti-disease agent or combination of agents. Usually called "phase I" or "phase I/II" trials, these experiments typically have the nominal scientific goal of determining an acceptable dose, most often based on adverse event probabilities.
arxiv +1 more source
Search and capture efficiency of dynamic microtubules for centrosome relocation during IS formation [PDF]
Biophysical Journal (2019), 2019 Upon contact with antigen presenting cells (APCs) cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) towards the contact zone, which necessitates a proper connection between MTOC and IS via dynamic ...
arxiv +1 more source
Smooth and probabilistic PARAFAC model with auxiliary covariates [PDF]
arXiv, 2021 In immunological and clinical studies, matrix-valued time-series data clustering is increasingly popular. Researchers are interested in finding low-dimensional embedding of subjects based on potentially high-dimensional longitudinal features and investigating relationships between static clinical covariates and the embedding.
arxiv
Journal of Immunology, 2019 Key Points IgG fucosylation status and target cell Ag density determine NK cell ADCC. Aspecific serum IgG bound to FcγRIIIa and target cell glycocalyx limit NK cell ADCC. NK cell FcγRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.
A. R. Temming +13 more
semanticscholar +1 more source
A statistical mechanics approach to autopoietic immune networks [PDF]
, 2010 The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may stem. In order to make theoretical immunology appealing to the statistical physicist audience we are going to ...
arxiv +1 more source
Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines [PDF]
arXiv, 2020 A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 + 0.31 to 438.3 3.3 {\mu}M as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 2.
arxiv
Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis [PDF]
, 2016 Background: Bovine necrohemorrhagic enteritis is caused by Clostridium perfringens type A. Due to the rapid progress and fatal outcome of the disease, vaccination would be of high value. In this study, C.
Deprez, Piet +10 more
core +2 more sources