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SOP/DTX/155 Cytotoxicity Tests

1980
Since chemicals may interact with cells in a variety of ways, the criteria for defining a toxic concentration depends on the technique used to measure toxicity. Thus toxicity can be expressed in terms of the doses of chemical which inhibit colony formation, cause detachment of cells from glass or plastic, inhibit DNA, RNA or protein synthesis, cause ...
I. P. Sword, Ritchie Thomson
openaire   +3 more sources

Cytotoxicity tests of water soluble ZnS and CdS quantum dots.

Journal of Nanoscience and Nanotechnology, 2011
Cytotoxicity tests of zinc sulfide (ZnS) and cadmium sulfide (CdS) quantum dots (QDs) synthesized via all-aqueous process with various surface conditions were carried out with human endothelial cells (EA hy926) using two independent viability assays, i.e.
Hui Li   +4 more
semanticscholar   +1 more source

Neutral Red Uptake Cytotoxicity Tests for Estimating Starting Doses for Acute Oral Toxicity Tests

Current Protocols in Toxicology, 2008
In vitro cytotoxicity assays can be used as alternative toxicity tests to reduce the total number of animals needed for acute oral toxicity tests. This unit describes two methods for determining the in vitro cytotoxicity of test substances using neutral ...
W. Stokes   +3 more
semanticscholar   +1 more source

The Cytotoxic Test for Leucocyte Antibodies

Vox Sanguinis, 1965
RésuméLes auteurs décrivent une technique pour déterminer les iso‐anticorps cytotoxiques contre les leucocytes humains et présentent une critique concernant les facteurs variables qui peuvent intervenir dans les tests. Ces tests ne requièrent pas d'équipement ou d'habileté spéciale; ils sont rapides à pratiquer et donnent des résultats étonamment ...
C. P. Engelfriet, A. Britten
openaire   +3 more sources

An approach to avoiding errors in cytotoxic testing

Journal of Immunological Methods, 1973
Abstract It is shown that time and temperature influence the results of cytotoxic assays considerably. In order to avoid errors depending upon these factors a simple modification in counting the cells is recommended.
H.-G. Thiele, H. Zimpel, R. Stark
openaire   +3 more sources

Comparative studies of the toxicity of standard reference materials in various cytotoxicity tests and in vivo implantation tests.

Journal of Applied Biomaterials, 1993
Polyurethane films that contained various amounts of zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) were prepared as standard reference materials (SRM).
T. Tsuchiya   +8 more
semanticscholar   +1 more source

Cytotoxicity Testing of Tomatine

1998
Glycoalkaloids, e.g. solanine and tomatine are found in potato, tomato and other plants. They are toxic to animals. It is difficult to analyze them in food. We developed a bioassay of tomatine. A combination method of HepG2 cell with a chemiluminescent was more easy to operate and rapid than others.
Daio Kozuka   +3 more
openaire   +2 more sources

Toxicological testing of cytotoxic drugs (Review)

International Journal of Oncology, 2001
Cytotoxic drugs are a unique therapeutic class of fundamental importance in current antineoplastic chemotherapy. These drugs belong to many chemical and chemotherapeutic classes. They are cytotoxic by design and are able to cause serious dose-limiting adverse effects at therapeutic doses.
M Iatropoulos   +3 more
openaire   +3 more sources

Modification of the FRAME Kenacid Blue Method for Cytotoxicity Tests on Volatile Materials

, 1992
In attempts to overcome the problem for cell culture cytotoxicity tests represented by highly volatile test materials, the wells of 96-well tissue culture plates were sealed individually, either by means of adhesive plastic film spread across the whole ...
L. Smith   +3 more
semanticscholar   +1 more source

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