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Uridine uptake inhibition as a cytotoxicity test: Correlations with the Draize test
Toxicology, 1984The effects of 25 xenobiotic chemicals on the uptake of [3H]-uridine by Balb/c 3T3 cells were assessed. The test compounds, which included alcohols, ethers, esters, ketones, amides, acids and a detergent, inhibited uridine uptake at concentrations lower than those required to kill the cells; thus uridine uptake inhibition is a more sensitive indicator ...
Sonal Sathe, C. Shopsis
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Cytotoxicity, Cytogenotoxicity and Allergenicity Tests on Certain Pyrethroids
Drug and Chemical Toxicology, 1987Pyrethroids are potent synthetic insecticides which have been increasingly employed in recent years. Such compounds have been shown to bind covalently to hepatic proteins. Covalent binding is often associated with toxic effects. Possible cytotoxic, cytogenotoxic and allergenic effects could be due to covalent binding of these compounds and/or their ...
H. Hoellinger +5 more
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Cytotoxicity Testing: Cell Experiments
2011Screening for new anticancer agents has traditionally been done with in vitro cell culture methods. Even in the genomic era of target-driven drug design, screening for cytotoxic activity is still a standard tool in the search for new anticancer agents, especially if the mode of action of a substance is not yet known.
Aron F. Westendorf +5 more
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Testing for food allergy: A statistical comparison of cytotoxic and intracutaneous tests
The Laryngoscope, 1978AbstractThis study presents a comparison of in vitro cytotoxic food allergy test results with those of in vivo intracutaneous food allergy testing by both objective serial dilution titration and subjective provocation. During the study the cytotoxic test was utilized as a screening device for follow‐up Lee intracutaneous testing, the latter providing ...
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Cytotoxicity Test for Bioceramics of Calcium Phosphate
Materials Science Forum, 1998Calcium and phosphor compounds have been used as biomaterials in the medical and odontological field to replace bone tissue. Calcium pyrophosphate (Ca 2 P 2 O 7 ), synthetic hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] and natural hydroxyapatite from bovine bone were obtained by powder process, milled and characterized by chemical and crystallographic ...
Sizue Ota Rogero +2 more
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Tests Predictive of Cytotoxic Activity
1974Tests predictive of cytotoxicity are of three general types; those that select agents for antitumor cytotoxicity, those that predict host cytotoxicity, and those applied to predict the toxicity/benefit ratio of a drug of generally accepted potency in a particular patient with a specific tumor.
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Cytotoxicity Testing for Food Safety Evaluation
1995We have been interested in studying the factors affecting the quality of food. It is important to detect toxic substances in foods as well as to control food-born disease microorganisms. We have been applied in vitro bioassay to evaluate the quality of food.
Kenji Isshiki +2 more
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SOP/DTX/155 Cytotoxicity Tests
1980Since chemicals may interact with cells in a variety of ways, the criteria for defining a toxic concentration depends on the technique used to measure toxicity. Thus toxicity can be expressed in terms of the doses of chemical which inhibit colony formation, cause detachment of cells from glass or plastic, inhibit DNA, RNA or protein synthesis, cause ...
I. P. Sword, Ritchie Thomson
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Cytotoxicity Testing for Evaluating Food Safety
2005Different cytotoxicity tests are used to determine food safety. We propose rapid cytotoxicity testing based on menadione-catalyzed H2O2 production by viable cells, which depends on both intracellular NAD(P)H concentration and plasma membrane-bound quinone oxidoreductase (EC 1.6.99.2).
Kenji Isshiki, Shiro Yamashoji
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Cytotoxic Food Testing in Alcoholics
Quarterly Journal of Studies on Alcohol, 1974George A. Ulett +2 more
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