Results 61 to 70 of about 283,958 (307)

Impacts of in vivo and in vitro exposures to tamoxifen: comparative effects on human cells and marine organisms [PDF]

, 2019
Tamoxifen (TAM) is a first generation-SERM administered for hormone receptor-positive (HER+) breast cancer in both pre- and post-menopausal patients and may undergo metabolic activation in organisms that share similar receptors and thus face comparable ...
Abessa, D. M. S., Bebianno, M., Carriço, T., Fernandes, E., Fonseca, T. G., Tavares, A.   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cytotoxicity of Different Concentrations of Silver Nanoparticles and Calcium Hydroxide for MC3T3‐E1 Preosteoblast Cell Line

Clinical and Experimental Dental Research
Introduction With the advances in nanotechnology, nanomaterials are increasingly used in various fields due to their antibacterial properties; therefore, assessing the benefits and risks associated with the application of medicaments is imperative.
Farzaneh Afhkami, Paniz Ahmadi, Golriz Rostami   +2 more
doaj   +1 more source

Avaliação da biocompatibilidade de vidro e vitrocerâmica do sistema SNCP (SiO2-Na2O-CaO-P2O5)

Química Nova, 2012
This article reports research results related to bioactivity and cytotoxicity tests using neutral red uptake method for glass powders and bulk glass ceramics belonging to the SNCP (SiO2-Na2O-CaO-P2O5) system.
Karoline Bastos Mundstock, Antonio Pedro Novaes de Oliveira, Dachamir Hotza, Sizue Ota Rogero   +3 more
doaj   +1 more source

Biological activities of ethanolic extracts from deep-sea antarctic marine sponges [PDF]

, 2013
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth ...
Ambrožič Avguštin, Jerneja, Batista, Urška, Janussen, Dorte, Kauferstein, Silke, Kosmina, Rok, Mebs, Dietrich, Sepčić, Kristina, Strugar, Gašper, Turk, Tom, Čivović, Sandra   +9 more
core   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Considerations Regarding the Cytotoxicity of Certain Classes of Fungal Polyketides—Potential Raw Materials for Skincare Products for Healthy and Diseased Skin

Pharmaceutics
Background: This study investigates the cytotoxicity of microbial polyketides biosynthesized by Monascus species through both in silico and in vitro approaches.
Daniela Albisoru, Nicoleta Radu, Raluca Senin, Mihai Dan Caramihai, Mihaela Begea, Oksana Mulesa, Viviana Roman, Marinela Bostan   +7 more
doaj   +1 more source

In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants

Molecules, 2020
One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility ...
Petra Arany, Ildikó Papp, Marianna Zichar, Máté Csontos, János Elek, Géza Regdon, István Budai, Mónika Béres, Rudolf Gesztelyi, Pálma Fehér, Zoltán Ujhelyi, Gábor Vasvári, Ádám Haimhoffer, Ferenc Fenyvesi, Judit Váradi, Vecsernyés Miklós, Ildikó Bácskay   +16 more
doaj   +1 more source

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells [PDF]

, 2010
Background - Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood.
Alink, G.M., Bhattacharjee, S., Evers, N.M., Haan, L.H.J., de, Jiang, X., Marcelis, A.T.M., Rietjens, I.M.C.M., Zuilhof, H.   +7 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source