Results 71 to 80 of about 13,799,457 (333)
Important Parameters in Cytotoxicity Testing of Nanoparticles [PDF]
Scientia Pharmaceutica, 2010 Background: The use of nano-sized materials (NMs) offers exciting new options in technical and medical applications. Adverse effects on cells and organs, however, [...]
Eva Roblegg +3 more
openaire +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
An evaluation for the standardization of the Allium cepa test as cytotoxicity and genotoxicity assay
Caryologia (Firenze), 2018 A general report on the use of the Allium test as cytotoxicological and genotoxicological assay is proposed, with particular emphasis about the standardization of the test in several common applications.
E. Bonciu +15 more
semanticscholar +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
International Journal of Molecular Sciences, 2018 Zn-based biodegradable metallic materials have been regarded as new potential biomaterials for use as biodegradable implants, mainly because of the ideal degradation rate compared with those of Mg-based alloys and Fe-based alloys.
Ping Li +8 more
semanticscholar +1 more source
Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
wiley +1 more source
Application of Chemiluminescent Assay in Cytotoxicity Tests
Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1997 This study showed that chemiluminescent (CL) assay is superior to Giemsa staining assay or MTT reduction assay in sensitivity and rapidity for detection of the cytotoxic effects of four compounds (phenobarbital sodium, theophyllin, propranolol and thioridazine).
Kazuko Kitamura, Yoshihide Suwa
openaire +3 more sources
Comparison between direct contact and extract exposure methods for PFO cytotoxicity evaluation
Scientific Reports, 2018 A series of recent acute blindness cases following non–complicated retinal detachment surgery caused the release of several health alerts in Spain. The blindness was attributed to certain lots of perfluoro-octane (PFO; a volatile and transient medical ...
Girish K Srivastava +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Study of the in vitro cytotoxicity testing of medical devices.
Biomedical Reports, 2015 The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cells in vitro to observe the cell growth, reproduction and morphological effects by medical devices.
Weijia Li, Jing Zhou, Yuyin Xu
semanticscholar +1 more source