Results 1 to 10 of about 14,369,746 (295)

Effects of amphetamine administration on neurogenesis in adult rats

Folia Neuropathologica, 2017
In our study expression of phospho-(Ser-10)-histone H3 (pH3S10), a marker for the early stage of neurogenesis, and cellular early response genes were investigated using c-Fos protein as an example of a transcription factor in the neurogenic process in ...
Tomasz Stępień, Ewa Taracha, Ewelina Kaniuga, Adam Płaźnik, Teresa Wierzba-Bobrowicz   +4 more
doaj   +2 more sources

Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats [PDF]

Journal of Integrative Neuroscience, 2022
Locomotor hyperactivity induced by psychotomimetic drugs, such as amphetamine and phencyclidine, is widely used as an animal model of psychosis-like behaviour and is commonly attributed to an interaction with dopamine release and N-methyl-D-aspartate (
Snezana Kusljic, Maarten van den Buuse, Andrea Gogos   +2 more
doaj   +1 more source

Performance deficits of NK1 receptor knockout mice in the 5-choice serial reaction-time task: effects of d-amphetamine, stress and time of day. [PDF]

PLoS ONE, 2011
BackgroundThe neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD).
Ting Carrie Yan, Julia A Dudley, Ruth K Weir, Ewelina M Grabowska, Yolanda Peña-Oliver, Tamzin L Ripley, Stephen P Hunt, David N Stephens, S Clare Stanford   +8 more
doaj   +1 more source

Effects of Food on the Bioavailability of Amphetamine in Healthy Adults After Administration of SHP465 Mixed Amphetamine Salts Extended-Release Capsules

Drugs in R&D, 2019
Background and objective SHP465 mixed amphetamine salts extended release is a once-daily, single-entity, mixed amphetamine salts capsule product for attention-deficit/hyperactivity disorder.
Yi Wang, Ming Yu, Brian Yan, Patrick Martin, Brigitte Robertson   +4 more
doaj   +1 more source

l-Amphetamine improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD)

Behavioral and Brain Functions, 2008
Background ADHD is currently defined as a cognitive/behavioral developmental disorder where all clinical criteria are behavioral. Overactivity, impulsiveness, and inattentiveness are presently regarded as the main clinical symptoms.
Xu Tong, Sagvolden Terje
doaj   +1 more source

Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine

Brain Sciences, 2021
Evidence suggests that nicotine and alcohol can each serve as a gateway drug. We determined whether prior nicotine and alcohol treatment would alter amphetamine reward.
Andrea Stojakovic, Syed Muzzammil Ahmad, Kabirullah Lutfy   +2 more
doaj   +1 more source

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder

Metabolites, 2022
Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed
Fawaz Alasmari, Mohammed A. Assiri, Syed Rizwan Ahamad, Sahar R. Aljumayi, Wedad H. Alotaibi, Majd M. Alhamdan, Khalid Alhazzani, Metab Alharbi, Faleh Alqahtani, Abdullah F. Alasmari   +9 more
doaj   +1 more source

Combination of modafinil and d-Amphetamine for the treatment of cocaine dependence: A preliminary investigation

Frontiers in Psychiatry, 2012
Background: Two stimulant medications, modafinil and d-amphetamine, when tested individually, have shown safety and efficacy for treatment of cocaine addiction.
Joy M Schmitz, Nuvan eRathnayaka, Charles eGreen, F Gerard eMoeller, Anne E Dougherty, John eGrabowski   +5 more
doaj   +1 more source

Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals

iScience, 2023
Summary: The glycine receptor alpha 2 (GlyRα2) is a ligand-gated ion channel which upon activation induces a chloride conductance. Here, we investigated the role of GlyRα2 in dopamine-stimulated striatal cell activity and behavior. We show that depletion
Jens Devoght, Joris Comhair, Giovanni Morelli, Jean-Michel Rigo, Rudi D'Hooge, Chadi Touma, Rupert Palme, Ilse Dewachter, Martin vandeVen, Robert J. Harvey, Serge N. Schiffmann, Elisabeth Piccart, Bert Brône   +12 more
doaj   +1 more source

Comparison of the efficacy of two anticonvulsants, phenytoin and valproate to improve PCP and d-amphetamine induced deficits in a reversal learning task in the rat

Frontiers in Behavioral Neuroscience, 2009
Recent studies in our laboratory have shown that PCP (phencyclidine) and d-amphetamine induce a cognitive deficit in rats, in a paradigm of potential relevance for the pathology of schizophrenia.
Nagi F Idris, JO C Neill, Charles H Large   +2 more
doaj   +1 more source