Results 151 to 160 of about 13,512,755 (196)

Combined effects of modafinil and d-amphetamine in male Sprague–Dawley rats trained to discriminate d-amphetamine

Pharmacology Biochemistry and Behavior, 2013
Modafinil is a novel wake-promoting drug with FDA approval for the treatment of sleep-related disorders that has recently been investigated as a potential agonist replacement therapy for psychostimulant dependence. Previous research in animals and humans indicates modafinil has a lower abuse liability than traditional psychostimulants, although few ...
Amanda J, Quisenberry, Thomas, Prisinzano, Lisa E, Baker   +2 more
openaire   +2 more sources

The effects of d-amphetamine on visual sensitivity in the rat

European Journal of Pharmacology, 1983
Abstract The visual sensitivity of rats was studied under four dose levels of dextroamphetamine sulfate. It was found that drug administration produced a significant dose-related decrease in visual sensitivity. The results are discussed in terms of the possible sites of action of the drug that might produce such results.
V L, Goetsch, W, Isaac
openaire   +2 more sources

Mechanism of d-amphetamine inhibition of protein synthesis

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
At 1 h after intraperitoneal administration of D-amphetamine sulphate (15 mg/kg), rat brain polyribosomes show disaggregation accompanied by reduced capacity for in vitro peptide chain elongation. The direct action of amphetamine on cell-fine protein-synthesizing systems was therefore explored. When brain or liver polyribosomes from untreated rats were
B S, Baliga, J, Zähringer, M, Trachtenberg, M A, Moskowitz, H N, Munro   +4 more
openaire   +2 more sources

Effects of d-amphetamine on speaking in isolated humans

Pharmacology Biochemistry and Behavior, 1978
The effects of oral d-amphetamine, 5--20 mg were studied in isolated humans who produced speech monologues during experimental sessions. Drug effects were studied under double-blind conditions by making repeated observations within each subject after placebo or active drug. In the first experiment, d-amphetamine 15 mg was studied in 4 isolated subjects
M L, Stitzer, R R, Griffiths, I, Liebson
openaire   +2 more sources

Modulation of use‐dependent plasticity by d‐amphetamine

Annals of Neurology, 2001
AbstractUse‐dependent plasticity, thought to contribute to functional recovery after brain injury, is elicited by motor training. The purpose of this study was to determine if administration of d‐amphetamine facilitates the effects of motor training on use‐dependent plasticity.
Cathrin M, Bütefisch, Benjamin C, Davis, Lumy, Sawaki, Daniel, Waldvogel, Joseph, Classen, Leonid, Kopylev, Leonardo G, Cohen   +6 more
openaire   +2 more sources

Behavioral effects of d-amphetamine in developing cats

Developmental Brain Research, 1985
The development of the behavioral effects of amphetamine was assessed in kittens of 1-53 days of age. Amphetamine-induced increases in locomotion occurred when animals were beyond 35 days of age. Stereotypic behavior was induced at all ages tested but the predominant type of stereotypy was age-related.
M S, Levine, J H, Hannigan, R S, Fisher, S, Howard-Butcher, C D, Hull, N A, Buchwald   +5 more
openaire   +2 more sources

d-amphetamine and adjunctive drinking in rats

Psychopharmacology, 1977
In the first experiment four food-deprived rats developed high levels of adjunctive water drinking during daily sessions of intermittent food pellet delivery. When the water was removed and a solution of d-amphetamine sulfate (0.01 mg/ml) put in its place, adjunctive drinking was disrupted towards the end of each session although the rats ingested ...
openaire   +2 more sources

Effects of D-amphetamine on temporal discrimination in pigeons

Behavioural Pharmacology, 2005
Two experiments used a matching to sample of durations procedure to examine changes in temporal discrimination evoked by D-amphetamine (0.75, 1.50, 2.25 and 3.0 mg/kg i.m.) in pigeons. Responses to one key color were reinforced after long (8-s) stimuli: responses to the alternative key color were reinforced after short (2-s) stimuli.
E A, McClure, K A, Saulsgiver, C D L, Wynne   +2 more
openaire   +2 more sources

Effects of methylphenidate and d-amphetamine on timing in the rat

Pharmacology Biochemistry and Behavior, 1987
Rats were trained to press a lever for food pellets provided according to a fixed interval 60-sec schedule of reinforcement. Probe trials (peak trials) assessed responding over two-min periods with no pellet delivered. The low rates of responding found early and late in probe trials were increased by methylphenidate and 1.0 mg/kg d-amphetamine (rate ...
D A, Eckerman, D, Segbefia, S, Manning, G S, Breese   +3 more
openaire   +2 more sources

Effect of fenfluramine on the d-amphetamine toxicity in mice

European Journal of Pharmacology, 1969
Abstract The toxicity of d-amphetamine in grouped mice is antagonized by theanorexic drug fenfluramine but not by its derivative S 992. The protection of the d-amphetamine toxicity in grouped mice correlates with a decrease in the hyperthermic effect of d-amphetamine.
S, Jespersen, A, Bonaccorsi
openaire   +2 more sources