Results 151 to 160 of about 14,369,746 (295)

D-Amphetamine-Elicited Action Potential Bursts in Central Snail Neurons: Role of Second Messenger Systems

open access: yes, 2009
Background and Purpose: Neuronal bursts of action potentials are closely related to seizure activity. Amphetamine rarely induces seizures at therapeutic doses, but seizure may Occur after the first dose.
TSAI, MING-CHENG, 蔡明正
core  

Straddling “The Gulf Between Medicine and Law”: Medico‐legal addiction and Japanese psychiatry

open access: yesMedical Anthropology Quarterly, EarlyView.
Abstract Increasing punitive drug regulations in Japan amplify longstanding tensions within psychiatric practice, pushing psychiatrists to balance clinical obligations with complex socio‐legal demands. This article analyzes how psychiatrists specializing in illicit substance use disorders to navigate escalating criminalization by developing diagnostic ...
Selim Gokce Atici
wiley   +1 more source

“They need to get a new program”: Experiential frictions with the gender of care in the 12 step program for ethnically Mexican women

open access: yesMedical Anthropology Quarterly, EarlyView.
Abstract Using gender as an analytic, I parse out how the historical gendered, classed, and racialized roots of the 12 Step Program remain present in its therapeutic model, even in global contexts beyond its original formulation. These foundations continue to shape therapeutic logics and experience within the Program, in positive and negative ways.
Ellen E. Kozelka
wiley   +1 more source

Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)

open access: yesObesity Reviews, EarlyView.
Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo   +13 more
wiley   +1 more source

Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration. [PDF]

open access: yesDrug Alcohol Depend, 2020
Langenecker SA   +8 more
europepmc   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

open access: yesObesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati   +12 more
wiley   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

open access: yesOral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung   +4 more
wiley   +1 more source

Parkinson's disease under dopamine replacement therapy as a human framework for studying addiction‐relevant mechanisms

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Addiction is a chronic relapsing condition characterized by compulsive reward seeking and impaired behavioral control, associated with major individual and societal burden. Mechanistic investigation in humans remains constrained by ethical limitations, uncontrolled exposure histories, and ecological confounds.
Vanessa Fleury   +6 more
wiley   +1 more source

Elevated Levels of Blood Neurofilament Light Chain in Substance‐Using Populations: A Systematic Review and Meta‐Analysis

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Substance‐use disorders are increasingly linked to structural and functional brain alterations consistent with neuroaxonal injury. Neurofilament light chain (NfL) is a sensitive blood‐based marker of axonal damage, but evidence in substance‐using populations remains fragmented.
João Antônio Valadão Leal   +2 more
wiley   +1 more source

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