Results 91 to 100 of about 13,822,372 (257)

Factors associated with D-dimer levels in HIV-infected individuals.

PLoS ONE, 2014
BackgroundHigher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood.MethodsIn this cross-sectional study, participants in three ...
Alvaro H Borges, Jemma L O'Connor, Andrew N Phillips, Jason V Baker, Michael J Vjecha, Marcelo H Losso, Hartwig Klinker, Gustavo Lopardo, Ian Williams, Jens D Lundgren, INSIGHT SMART Study Group, ESPRIT Study Group, SILCAAT Scientific Committee   +12 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

D-Dimer in African Americans [PDF]

, 2017
Objective— Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men.
Rich, Stephen S, Cecelia Laurie, Duan, Qing, Peter Durda, Jerome I. Rotter, Rotter, Jerome I, Joshua D. Smith, Nickerson, Deborah A, Ethan M. Lange, Marguerite R. Irvin, Naik, Rakhi P, Adolfo Correa, Kenneth Rice, Jenny, Nancy S, Leslie A. Lange, Reiner, Alex P, Liu, Yongmei, Durda, Peter, Cushman, Mary, Irvin, Marguerite R, Smith, Joshua D, Andrew D. Johnson, Wilson, James G, Raffield, Laura M, Li, Yun, Yongmei Liu, Lange, Ethan M, Yun Li, Laurie, Cecelia, Zakai, Neil A, Manichaikul, Ani W, Stephen S. Rich, Rakhi P. Naik, Lange, Leslie A, Ani W. Manichaikul, Correa, Adolfo, Ci Song, Doyle, Margaret F, Mary Cushman, Alex P. Reiner, Neil A. Zakai, Rice, Kenneth, Song, Ci, Deborah A. Nickerson, Nancy S. Jenny, Laura M. Raffield, Qing Duan, Margaret F. Doyle, James G. Wilson, Johnson, Andrew D   +49 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

, 2007
Aims The aim of the study was to ascertain whether there is variation in the fibrinolytic/coagulation component of diabetes associated with disease progression to macrovascular complications and whether D-dimer can discriminate such variation. Methods A
Jelinek, Herbert F., Nwose, Ezekiel U., Kerr, Philip G., Richards, Ross S.   +3 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Post-procedural plasma D-dimer level may predict futile recanalization in stroke patients with endovascular treatment

Journal of Stroke and Cerebrovascular Diseases
Objective: High d-dimer levels may increase the likelihood of unfavorable clinical outcomes in patients with acute ischemic stroke. However, the impacts of serum d-dimer levels on outcomes of reperfusion treatment in patients with acute ischemic stroke ...
Min Zhao, MD, Zhengze Dai, MD, Rui Liu, MD, Xinfeng Liu, MD, PhD, Gelin Xu, MD, PhD   +4 more
doaj   +1 more source