Results 81 to 90 of about 10,603,245 (304)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19

Respiratory Research, 2020
Background Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of death.
Wenjing Ye, Guoxi Chen, Xiaopan Li, Xing Lan, Chen Ji, Min Hou, Di Zhang, Guangwang Zeng, Yaling Wang, Cheng Xu, Weiwei Lu, Ruolin Cui, Yuyang Cai, Hai Huang, Ling Yang   +14 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients

Scientific Reports, 2021
To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to ...
Xiaokang He, Fei Yao, Jie Chen, Yan Wang, Xiangming Fang, Xuan Lin, Hui Long, Qiang Wang, Qingming Wu   +8 more
doaj   +1 more source

D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

, 2007
Aims The aim of the study was to ascertain whether there is variation in the fibrinolytic/coagulation component of diabetes associated with disease progression to macrovascular complications and whether D-dimer can discriminate such variation. Methods A
Jelinek, Herbert F., Nwose, Ezekiel U., Kerr, Philip G., Richards, Ross S.   +3 more
core   +1 more source

D-Dimer in African Americans [PDF]

, 2017
Objective— Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men.
Rich, Stephen S, Cecelia Laurie, Duan, Qing, Peter Durda, Jerome I. Rotter, Rotter, Jerome I, Joshua D. Smith, Nickerson, Deborah A, Ethan M. Lange, Marguerite R. Irvin, Naik, Rakhi P, Adolfo Correa, Kenneth Rice, Jenny, Nancy S, Leslie A. Lange, Reiner, Alex P, Liu, Yongmei, Durda, Peter, Cushman, Mary, Irvin, Marguerite R, Smith, Joshua D, Andrew D. Johnson, Wilson, James G, Raffield, Laura M, Li, Yun, Yongmei Liu, Lange, Ethan M, Yun Li, Laurie, Cecelia, Zakai, Neil A, Manichaikul, Ani W, Stephen S. Rich, Rakhi P. Naik, Lange, Leslie A, Ani W. Manichaikul, Correa, Adolfo, Ci Song, Doyle, Margaret F, Mary Cushman, Alex P. Reiner, Neil A. Zakai, Rice, Kenneth, Song, Ci, Deborah A. Nickerson, Nancy S. Jenny, Laura M. Raffield, Qing Duan, Margaret F. Doyle, James G. Wilson, Johnson, Andrew D   +49 more
core   +1 more source

Renal Function-Adjusted D-Dimer Levels in Critically Ill Patients With Suspected Thromboembolism. [PDF]

, 2020
OBJECTIVES Diagnosing thromboembolic disease typically includes D-dimer testing and use of clinical scores in patients with low to intermediate pretest probability.
Angehrn, Michelle C., Leichtle, Alexander B., Pfortmüller, Carmen, Fiedler, Georg M., Anna S. Messmer, Gerber, Joël L., Messmer, Anna S., Martin Müller, Alexander B. Leichtle, Joerg C. Schefold, Michelle C. Angehrn, Georg M. Fiedler, Carmen A. Pfortmueller, Schefold, Joerg C., Müller, Martin, Aristomenis K. Exadaktylos, Exadaktylos, Aristomenis, Joël L. Gerber   +17 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

D-dimer levels in pleural effusions [PDF]

Respiratory Medicine, 2006
D-dimer is a degradation product of cross-linked fibrin. We hypothesized that hemorrhagic pleural effusions would have greater D-dimer levels than non-hemorrhagic pleural effusions, and that persistently bloody effusions would be distinguishable from thoracentesis-induced bloody effusions by the D-dimer level.Forty pleural effusions were studied.
Dikensoy, O., Stathopoulos, G.T., Zhu, Z., Light, R.W.   +3 more
openaire   +2 more sources