Results 121 to 130 of about 15,447,907 (346)

Prolonged elevations in haemostatic and rheological responses following psychological stress in low socioeconomic status men and women [PDF]

, 2003
Low socioeconomic status (SES) and psychological stress are associated with increased risk of coronary heart disease, and both may influence haemostatic responses.
Kunz-Ebrecht, S., Lowe, G.D.O., Rumley, A., Steptoe, A.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation

Clinical Chemistry and Laboratory Medicine, 2020
Coronavirus disease 2019 (COVID-19) represents a new pandemic caused by severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2). A previous pooled analysis clearly identified elevated D-dimer levels as being associated with severity of COVID ...
E. Favaloro, J. Thachil
semanticscholar   +1 more source

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial [PDF]

, 2018
Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH.
Adetayo, Cecilia, Aimakhu, Chris, Balogun, Eni, Bello, Adenike, Dallaku, Kastriot, Fawole, Bukola, Hunt, Beverley, Huque, Sumaya, Kotila, Taiwo, Kuti, Modupe, Mansmann, Ulrich, Ogunbode, Olayinka, Okunade, Olujide, Olayemi, Oladapo, Olutogun, Tolulase, Pepple, Tracey, Roberts, Ian, Shakur-Still, Haleema   +17 more
core   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

D-dimer in patients infected with COVID-19 and suspected pulmonary embolism

Respiratory Medicine, 2020
Objective To analyze the risk factors for pulmonary embolism (PE) in patients infected with COVID-19. Methods We conducted an observational, retrospective study. Patients with severe infection with COVID-19 and suspected PE were included.
I. García-Olivé, H. Sintes, Joaquim Radua, J. Abad Capa, A. Rosell   +4 more
semanticscholar   +1 more source

Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study. [PDF]

, 2016
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 ...
Bahrami, Hossein, Budoff, Matthew, Haberlen, Sabina A, Ketlogetswe, Kerunne, Kingsley, Lawrence, McConnell, Michael V, Palella, Frank, Post, Wendy S, Rezaeian, Pantea, Tracy, Russell, Witt, Mallory D   +10 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

D-Dimer Testing in Pregnancy [PDF]

Pathophysiology of Haemostasis and Thrombosis, 2003
Normal pregnancy is associated with alterations of the hemostatic system toward a hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation, such as D-dimer, indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy.
openaire   +3 more sources

Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. [PDF]

, 2014
OBJECTIVES: To examine associations between sarcopenia, obesity, and sarcopenic obesity and risk of cardiovascular disease (CVD) and all-cause mortality in older men. DESIGN: Prospective cohort study.
Atkins, JL, Lennon, LT, Morris, RW, Papacosta, O, Wannamethee, SG, Whincup, PH   +5 more
core   +1 more source