Results 131 to 140 of about 15,447,907 (346)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

D‐dimer testing in clinical practice in the era of COVID‐19

Research and Practice in Thrombosis and Haemostasis, 2022
D‐dimer is a fragment of crosslinked fibrin resulting from plasmin cleavage of fibrin clots and hence an indirect biomarker of the hemostatic system activation.
Claire Auditeau, Lina Khider, Benjamin Planquette, Olivier Sanchez, David M. Smadja, Nicolas Gendron   +5 more
doaj   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors

Journal of Thrombosis and Thrombolysis, 2020
Coagulopathy in COVID-19 is a burning issue and strategies to prevent thromboembolic events are debated and highly heterogeneous. The objective was to determine incidence and risk factors of venous thromboembolism (VTE) in COVID-19 inpatients receiving ...
M. Artifoni, G. Danic, G. Gautier, Pascal Gicquel, D. Boutoille, F. Raffi, A. Néel, R. Lecomte   +7 more
semanticscholar   +1 more source

Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy. [PDF]

, 2017
We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain.
Adashek, Jacob, Ben-Zur, Uri M, Nagar, Menachem, Pietras, Richard J, Toomari, Nojan, Yaghoubian, Jonathan M, Yaghoubian-Yazi, Bahareh   +6 more
core   +5 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Association between D-Dimer levels and mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and pooled analysis

Journal de medecine vasculaire, 2020
Background Several observational studies have reported elevated baseline D-dimer levels in patients hospitalized for moderate to severe coronavirus disease 2019 (COVID-19). These elevated baseline D-dimer levels have been associated with disease severity
M. Sakka, Jean M. Connors, G. Hékimian, I. Martin-Toutain, B. Crichi, I. Colmegna, D. Bonnefont-Rousselot, Dominique Farge, Corinne Frere   +8 more
semanticscholar   +1 more source

Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis [PDF]

, 2005
Background Ultrasound (US) has largely replaced contrast venography as the definitive diagnostic test for deep vein thrombosis (DVT). We aimed to derive a definitive estimate of the diagnostic accuracy of US for clinically suspected DVT and identify ...
A Cogo, A Cogo, A Elias, A Elias, A Gongolo, A Markel, A Miselli, AF Aburahma, AG Aitken, AJ Comerota, AJ Comerota, AJ Sutton, Alex Sutton, AT Irvine, AW Lensing, B Kassai, B van Ramshorst, B Wolf, BD Lewis, BG Birdwell, BG Birdwell, BN Raghavendra, BS Hwang, C Kearon, C Savy-Stortz, D Becker, D Cavaye, D Gaitini, DA Kristo, DC Mitchell, DH O'Leary, DL Rollins, DP Flanigan, DR Anderson, E Bernardi, E Kalodiki, Edwin van Beek, EK Yucel, F Dany, F Pasquariello, FC Sampson, Fiona Sampson, FJ Song, G Guazzaloca, GJ Zhang, GM Baxter, GM Baxter, GP Shields, GP Size, GR Simons, GV Belcaro, H Bounameaux, H Heijboer, H Heijboer, H Rosier, HJ Aronen, HO Leven, I Baumgartner, J De Laveaucoupet, J Howe, J Yao, J Zamora, JC De Valois, JE George, JE George, JF Chance, JG Lijmer, JJ Cranley, JJ Cronan, JJ Deeks, JM Schindler, JP Carpenter, JP Fletcher, JP Laissy, JPJ Archie, JS Ginsberg, K Forbes, K Ouriel, K Walsh, LA Killewich, LW Tick, M Atri, M Dauzat, M Grobety, M Hay, M Mantoni, M Monreal, M Sluzewski, MA Amin, MA Mattos, MCG Holmes, ME McCandless, MJ Bradley, MK Eskandari, MK Zhou, N Labropoulos, N Miller, NH Rosner, OM Pedersen, P De Faucal, P Vogel, PJ Bendick, PL Robertson, PL Robertson, PR Biondetti, PS Wells, PS Wells, PS Wells, PS Wells, PS Wells, PT Appelman, PT Kennedy, R Lindqvist, R Mani, R Poti, R Puls, R Quintavalla, RA Bucek, RA Kraaijenhagen, RB Patterson, SC Rose, SG Thompson, SJ Theodorou, SM Bates, SM Schellong, SM Stevens, Steve Goodacre, Steve Thomas, SW Heim, TE Gudmundsen, TL Turnbull, W Habscheid, W Wysokinski, WD Foley   +133 more
core   +5 more sources