Results 51 to 60 of about 824,647 (268)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of Shear Wall-RC Frame Interaction of High-Rise Buildings using 2-D model Approach

Journal of Materials and Engineering Structures, 2015
The usefulness of structural walls in the framing of buildings has long been recognized. It is generally preferred to use shear wall in combination with moment resisting frame. In the present study, an effort is also made to investigate the shear wall-RC
Dipali Patel, Jignesh A Amin
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Frame-based block sparse compressed sensing via $$l_2/l_1$$ l 2 / l 1 -synthesis

EURASIP Journal on Advances in Signal Processing
In this paper, we consider the frame-based block sparse signal recovery via a $$l_2/l_1$$ l 2 / l 1 -synthesis method. A new kind of null space property based on the given dictionary D(block D-NSP) is proposed.
Fengong Wu, Penghong Zhong, Huasong Xiao, Chunmei Miao   +3 more
doaj   +1 more source

Steady-state Vibration Analysis of 3-D Frame Structures by Boundary Element Method.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1992
This paper is concerned with the boundary integral equation formulation and its numerical implementation for steady-state vibration analysis of spatial frame structures in the context of small elastic deformation and small strain theory. First, the integral equation formulation and its method of solution are presented in detail for a single straight ...
TANAKA, Masataka, MATSUMOTO, Toshiro, ARAI, Keisuke   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Depth perception of stereoscopic transparent stimuli with frame manipulation

Scientific Reports
Depth perception is crucial in human vision, allowing us to move and interact with our 3-D surroundings. We used a stereoscopic transparent stimulus comprising parallel overlapping transparent stereoscopic surfaces (POTS) to understand depth perception ...
Saori Aida, Shunta Fukamachi, Koichi Shimono   +2 more
doaj   +1 more source

On the nonstationarity of collisionless shocks and its impact on deriving the cross‐shock potential

Geophysical Research Letters, 2017
Recently, Comişel et al. (2015) suggested an adaptation of the deHoffmann‐Teller (HT) frame, to take into account the magnetic field fluctuations observed nearby and inside a quasi‐perpendicular collisionless shock.
Octav Marghitu, Horia Comişel, Manfred Scholer   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source