Results 161 to 170 of about 13,889,634 (275)

Intratumor <i>Lactobacillus</i> drives ferroptosis resistance via D-lactate-STAT3 K631 lactylation in esophageal squamous cell carcinoma. [PDF]

Gut Microbes
Wang D, Lu H, Li W, Li L, Xu X, Zhou H, Tao H, Li Y, Wei W, Wu K, Wang Y, Li R, Li Y, Yao W, Chen Y, Wang F, Ye L.   +16 more
europepmc   +1 more source

Elevated serum levels of diamine oxidase, D-lactate and lipopolysaccharides are associated with metabolic-associated fatty liver disease. [PDF]

Eur J Gastroenterol Hepatol, 2023
Zhang R, Chen YN, Zhang J, Liu J.
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Careful CO Addition Enhances Autotrophic d-Lactate Formation With Engineered <i>Acetobacterium woodii</i>. [PDF]

Eng Life Sci
Stock A, Sotzeck I, Baur K, Bengelsdorf F, Weuster-Botz D.   +4 more
europepmc   +1 more source

Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia. [PDF]

Sci Rep, 2021
Nuzzo A, Guedj K, Curac S, Hercend C, Bendavid C, Gault N, Tran-Dinh A, Ronot M, Nicoletti A, Bouhnik Y, Castier Y, Corcos O, Peoc'h K, SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center).   +13 more
europepmc   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer. [PDF]

JID Innov, 2021
Dikshit A, Lu J, Ford AE, Degan S, Jin YJ, Sun H, Nichols A, Salama AKS, Beasley G, Gooden D, Zhang JY.   +10 more
europepmc   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

The relationship between plasma lactate parameters, Wpeak and 1-h cycling performance in women

, 1998
PURPOSE: The relationship between six descriptors of lactate increase, peak VO2, Wpeak, and 1-h cycling performance were compared in 24 trained, female cyclists (peak VO(2) = 48.11 +/- 6.32 mLxkg(-1)xmin(-1).METHODS: The six descriptors of lactate ...
Mackinnon L. T., BISHOP, DAVID JOHN, Jenkins D. G.   +2 more
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