Results 91 to 100 of about 13,846,557 (251)

A Bacterial Multidomain NAD-Independent d -Lactate Dehydrogenase Utilizes Flavin Adenine Dinucleotide and Fe-S Clusters as Cofactors and Quinone as an Electron Acceptor for d -Lactate Oxidization

, 2017
Bacterial membrane-associated NAD-independent d -lactate dehydrogenase (Fe-S d -iLDH) oxidizes d -lactate into pyruvate. A sequence analysis of the enzyme reveals that it contains an
Jinxin Yan, Chao Gao, Tianyi Jiang, Ping Xu, Yingxin Zhang, Binbin Sheng, Cuiqing Ma, Xiaoting Guo, Manman Zhang, Yujiao Wang   +9 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

The role of respiratory D- - lactate dehydrogenase in the aerobic growth of ndh - deficient Zymomonas mobilis

, 2013
Darbā konstruēts baktērijas Zymomonas mobilis negatīvais mutants Zm6-ndh-ldh, un pētīta šī celma aerobā augšana un elpošana.Darba mērķis bija pētīt D - laktāta dehidrogenāzes funkcijas šīs baktērijas elektronu transporta ķēdē.
Alkšere, Baiba
core  

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A [PDF]

, 2010
Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies.
Illig, T, Spector Tim D., Kleber, M.E., März Winfried, Wichmann, H. -Erich, Mangino, M, Waldenberger, M, Hammond Christopher J., Prokopenko, I, Hammond, Christopher J., Blackburn Hannah, Prokisch Holger, Winkelmann Bernhard R., Mangino, M., H.-Erich Wichmann, Kovacs, P., Wichmann, H.-E., Marzi, C, Illig, T., Waldenberger, Melanie, Tim D Spector, Geistlinger, Ludwig, Tönjes, A, Koenig Wolfgang, Peters, Annette, Thorand, Barbara, Illig Thomas, Boehm, Bernhard O., Toenjes, Anke, Peters Annette, Boehm Bernhard O., Hysi, P.G., Kovacs, Peter, Prokisch, H., Mangino Massimo, Marcus E Kleber, Annette Peters, Prokopenko, I., Pirro G. Hysi, Soranzo, Nicole, Christopher J. Hammond, Hysi, Pirro G., Koenig, W, Tönjes Anke, Hammond, C.J., Heim, K., Harald Grallert, H-Erich Wichmann, Bernhard O. Boehm, Marzi, C., Koenig, W., Gieger, Christian, Eva Albrecht, Soranzo, N, Hammond, CJ, Albrecht Eva, Hysi Pirro G., Vasiliki Lagou, Grallert, H., Koenig, Wolfgang, Nicole Soranzo, Spector, Tim D., Gieger, C, Marz, W., Melanie Waldenberger, Michael Stumvoll, Thorand Barbara, Hysi, PG, Boehm, BO, Carola Marzi, Boehm, B.O., Janina S Ried, Lagou, Vasiliki, Wichmann, Heinz-Erich, Bernhard R. Winkelmann, Inga Prokopenko, Hannah Blackburn, Heim, Katharina, Kleber, ME, Peters, A, Stumvoll, M, Anke Tönjes, März, W, Gieger, C., Ried, Janina S., Christian Gieger, Ried, JS, Bernhard O Boehm, Albrecht, E, Blackburn, H, Stumvoll, M., Pirro G Hysi, Lagou Vasiliki, Ried Janina S., Waldenberger Melanie, Thorand, B, Christopher J Hammond, Lagou, V, Gieger Christian, Blackburn, Hannah, Grallert, Harald, Heim, K, Kleber Marcus E., Prokopenko Inga, Spector, T.D., Marzi, Carola, Waldenberger, M., Winkelmann, B.R., Heim Katharina, Wichmann H.-Erich, Kleber, Marcus E., Wolfgang Koenig, Barbara Thorand, Tönjes, A., Soranzo, N., Winfried März, Prokisch, Holger, Stumvoll, Michael, Marcus E. Kleber, Tim D. Spector, Mangino, Massimo, Stumvoll Michael, Grallert, H, Wichmann, HE, Geistlinger, L, Peters, A., Illig, Thomas, Maerz, Winfried, Ried, J.S., Grallert Harald, Thomas Illig, Albrecht, Eva, Lagou, V., Bernhard R Winkelmann, Kovacs Peter, Geistlinger Ludwig, Kovacs, P, Prokisch, H, Prokopenko, Inga, Katharina Heim, Marzi Carola, Soranzo Nicole, Massimo Mangino, Ludwig Geistlinger, Geistlinger, L., Blackburn, H., Peter Kovacs, Spector, TD, Janina S. Ried, Albrecht, E., Thorand, B., Winkelmann, BR, Winkelmann, Bernhard R., Holger Prokisch, Marzi, C;Albrecht, E;Hysi, PG;Lagou, V;Waldenberger, M;Tönjes, A;Prokopenko, I;Heim, K;Blackburn, H;Ried, JS;Kleber, ME;Mangino, M;Thorand, B;Peters, A;Hammond, CJ;Grallert, H;Boehm, BO;Kovacs, P;Geistlinger, L;Prokisch, H;Winkelmann, BR;Spector, TD;Wichmann, HE;Stumvoll, M;Soranzo, N;März, W;Koenig, W;Illig, T;Gieger, C   +154 more
core   +2 more sources

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Downhill Running-Induced Muscle Damage in Trail Runners: An Exploratory Study Regarding Training Background and Running Gait

Sports
This study aimed to assess the effect of a downhill-running (DR) bout on muscle damage biomarkers. It also examined whether training background and gait kinematics may influence DR-induced muscle damage and strength loss.
Ignacio Martinez-Navarro, Juan Vicente-Mampel, Raul López-Grueso, María-Pilar Suarez-Alcazar, Cristina Vilar-Fabra, Eladio Collado-Boira, Carlos Hernando   +6 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

D- and L-lactate dehydrogenase reactions increase pH to lactate production and decrease pH to pyruvate production

Frontiers in Molecular Biosciences
BackgroundThe traditional explanation of metabolic acidosis in extrahepatic tissues is the increased cellular production of lactic acid. We tested whether the LDH reaction produces lactate and pyruvate anions, or acids, and measured the pH changes that ...
Robert Robergs, Robert Robergs, Robert Robergs, Marek Nalos, Marek Nalos, Petr Kelbich, Adela Jizerová, Ivana Mervartová, Michal Vostrý, Milan Štengl, Vaclav Babuška   +10 more
doaj   +1 more source

Multiplex Real-Time Polymerase Chain Reaction on Sputum for the Diagnosis of Pneumocystis jirovecii Pneumonia in Children: A Retrospective Study

Infection and Drug Resistance, 2021
Juan Jiang,1,2 Xia Wang,3 Jian He,3 Donglei Liao,3 Xiaolu Deng3 1Department of Respiratory Medicine (National Key Clinical Specialty), Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Hunan Provincial Clinical Research ...
Jiang J, Wang X, He J, Liao D, Deng X
doaj