Results 111 to 120 of about 13,846,557 (251)

Kinetic characterization and structure analysis of an altered polyol dehydrogenase with d-lactate dehydrogenase activity. [PDF]

Protein Sci, 2020
Chauliac D, Wang Q, St John FJ, Jones G, Hurlbert JC, Ingram LO, Shanmugam KT.   +6 more
europepmc   +1 more source

Bio-Mimicking Pyruvate to Inhibit Lactate Dehydrogenase [PDF]

, 2012
Lactate dehydrogenase is an enzyme that catalyzes the reaction of converting pyruvic acid into lactic acid. This reaction took place at pH 7.0. Molecules, such as acetamide and oxamic acid, which are believed to mimic pyruvate in terms of hydrogen ...
Brockington, Davita Nicole, NC DOCKS at The University of North Carolina at Pembroke   +1 more
core  

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Genetic variability in three species of Gymnotus Linnaeus, 1758 (Gymnotiformes: Gymnotidae) from Caracu stream of the upper Paraná River basin, Brazil

Neotropical Ichthyology
The genetic variability of three Gymnotus species from the Caracu stream, a small tributary of the left margin of Paraná River (Brazilian upper Paraná River floodplain), was estimated with data of 17 putative allozyme loci, which were obtained by using ...
Judy Ruiz Rezende, Erasmo Renesto, Cláudio Henrique Zawadzki   +2 more
doaj   +1 more source

Lactate Dehydrogenase

, 2008
Bu ders notunda laktat dehidrogenaz enziminin üç boyutlu yapısı, koenzim ve kofaktörleri ile bazı özellikleri anlatılmaktadır.This lecture note is about the enzyme lactate dehydrogenase, its 3D structure, coenzymes and cofactors and some other ...
ERKOC, FIGEN
core  

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Desulfitobacterium elongatum sp. nov. NIT-TF6 Isolated from Trichloroethene-Dechlorinating Culture with Formate

Microorganisms
A strictly anaerobic bacterium denoted as strain NIT-TF6 of the genus Desulfitobacterium was isolated from a trichloroethene-dechlorinating culture with formate.
Udaratta Bhattacharjee, Ryuya Tomita, Li Xie, Naoko Yoshida   +3 more
doaj   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

A Comparative Study of Vitamin D Level and Lactate Dehydrogenase Activity in Relation to Oxidative Stress in Women with Osteoporosis

مجلة كلية الطب
Background: Osteoporosis (OP) is a silent disease that affects the microarchitecture of the skeleton bones, leading to a drop in mineral levels and an increase in fracture rates. This condition is more common in women than men, especially postmenopausal
Husham A. Abdlkarem, Jwan A. Zainulabdeen   +1 more
doaj   +1 more source