Results 121 to 130 of about 13,846,557 (251)

Pyruvate dehydrogenase : its structure, function and interactions within the pyruvate dehydrogenase multienzyme complex [PDF]

, 2002
Pyruvate dehydrogenase multi-enzyme complex (PDHC) is member of a family of multienzyme complexes that catalyse the irreversible decarboxylation of various 2-oxoacid substrates to their corresponding acyl-CoA derivatives, NADH and C02.
Hengeveld, A.F.
core  

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

A genome-reduced Corynebacterium glutamicum derivative discloses a hidden pathway relevant for 1,2-propanediol production

Microbial Cell Factories
Background 1,2-propanediol (1,2-PDO) is widely used in the cosmetic, food, and drug industries with a worldwide consumption of over 1.5 million metric tons per year.
Daniel Siebert, Erich Glawischnig, Marie-Theres Wirth, Mieke Vannahme, Álvaro Salazar-Quirós, Annette Weiske, Ezgi Saydam, Dominik Möggenried, Volker F. Wendisch, Bastian Blombach   +9 more
doaj   +1 more source

A D-lactate dehydrogenase from rice is involved in conferring tolerance to multiple abiotic stresses by maintaining cellular homeostasis. [PDF]

Sci Rep, 2020
Jain M, Aggarwal S, Nagar P, Tiwari R, Mustafiz A.   +4 more
europepmc   +1 more source

Stabilization of lactate dehydrogenase [PDF]

, 1972
Addition of substances such as dimethylsulfoxide, glycerol, and gelatin to aqueous solutions of lactate dehydrogenase maintains enzymes in stable and fully active form when stored at 2 - 6 ...
Friedman, O. M.
core  

Serum Levels of Lactate Dehydrogenase and Alkaline Phosphatase Enzymes in Colorectal Cancer

, 2019
Colorectal cancer (CRC) remains one of the main public health problems throughout the world. It has recently been observed that both of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) enzymes play critical role in cancer expansion.
Mohammed Imran Hamzah, Abeer Khalid Yaseen, Batool Hassan Al-Ghurabi   +2 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

PDLA a potential new potent topical analgesic: a case report

Local and Regional Anesthesia, 2014
Joel S Goldberg1,2 1Durham Veterans Affairs Medical Center, 2Duke University School of Medicine, Durham, NC, USA Abstract: Polymer D-lactic acid (PDLA) is a hydrogel that has been shown to sequester L-lactate (lactate).
Goldberg JS
doaj  

Dynamic changes and prognostic utility of procalcitonin, D-dimer, and lactate dehydrogenase in patients with sepsis and septic shock

Frontiers in Medicine
ObjectiveTo investigate whether serum levels of procalcitonin (PCT), D-dimer (D-D), and lactate dehydrogenase (LDH) are associated with disease severity and differ between patients with sepsis with favorable versus poor in-hospital outcomes.MethodsThis ...
Qiuxia Ge, Qiuxia Ge, Weijuan Song, Weijuan Song, Hongmei Ding, Hongmei Ding, Haojie Wu, Haojie Wu, Zhen Ren, Zhen Ren   +9 more
doaj   +1 more source

Enzymological characterization of a novel d-lactate dehydrogenase from Lactobacillus rossiae and its application in d-phenyllactic acid synthesis. [PDF]

3 Biotech, 2020
Luo X, Zhang Y, Yin F, Hu G, Jia Q, Yao C, Fu Y.   +6 more
europepmc   +1 more source