Results 31 to 40 of about 13,846,557 (251)

Purifying and Characterizing Bacterially Expressed Soluble Lactate Dehydrogenase from Plasmodium knowlesi for the Development of Anti-Malarial Drugs

Molecules, 2021
Plasmodium lactate dehydrogenase (pLH) is one of the enzymes in glycolysis with potential target for chemotherapy. This study aimed to clone, overexpress and characterize soluble recombinant lactate dehydrogenase from Plasmodium knowlesi in a bacterial ...
Nurhainis Ogu Salim, Fazia Adyani Ahmad Fuad, Farahayu Khairuddin, Wan Mohd Khairulikhsan Wan Seman, Mohd Anuar Jonet   +4 more
doaj   +1 more source

Kinetic activation of yeast mitochondrial d-lactate dehydrogenase by carboxylic acids [PDF]

, 2008
Aerobically grown yeast cells express mitochondrial lactate dehydrogenases that localize to the mitochondrial inner membrane. The d-lactate dehydrogenase is a zinc-flavoprotein with high acceptor specificity for cytochrome c, that catalyzes the oxidation
Rigoulet, M., Rigoulet, Michel, Devin, Anne, Vallortigara, J., Mourier, Arnaud, Mourier, A., Devin, A., Yoboué, E.D., Vallortigara, Julie, Yoboue, Edgar D.   +9 more
core   +1 more source

Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Cancer & Metabolism, 2021
Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate.
Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis, A. Dean Sherry   +6 more
doaj   +1 more source

CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

Signal Transduction and Targeted Therapy, 2023
Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma ...
Mengzhu Lv, Ying Gong, Xuesong Liu, Yan Wang, Qingnan Wu, Jie Chen, Qingjie Min, Dongyu Zhao, Xianfeng Li, Dongshao Chen, Di Yang, Danna Yeerken, Rui Liu, Jinting Li, Weimin Zhang, Qimin Zhan   +15 more
doaj   +1 more source

CRP Regulates D-Lactate Oxidation in Shewanella oneidensis MR-1

Frontiers in Microbiology, 2017
Shewanella oneidensis MR-1 is a heterotrophic facultative anaerobe that respires using various organic and inorganic compounds. This organism has served as a model to study bacterial metabolic and regulatory systems that facilitate their survival in ...
Takuya Kasai, Atsushi Kouzuma, Kazuya Watanabe   +2 more
doaj   +1 more source

The primary pathway for lactate oxidation in Desulfovibrio vulgaris

Frontiers in Microbiology, 2015
The ability to respire sulfate linked to lactate oxidation is a key metabolic signature of the Desulfovibrio genus. Lactate oxidation by these incomplete oxidizers generates reductants through lactate dehydrogenase (LDH) and pyruvate-ferredoxin ...
Laetitia ePieulle, Nicolas eVita, Odile eValette, Gaël eBrasseur, Sabrina eLignon, Yann eDenis, Mireille eAnsaldi, Alain eDolla   +7 more
doaj   +1 more source

Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells.

PLoS Pathogens, 2022
Haemophilus influenzae (Hi) infections are associated with recurring acute exacerbations of chronic respiratory diseases in children and adults including otitis media, pneumonia, chronic obstructive pulmonary disease and asthma.
Jennifer Hosmer, Marufa Nasreen, Rabeb Dhouib, Ama-Tawiah Essilfie, Horst Joachim Schirra, Anna Henningham, Emmanuelle Fantino, Peter Sly, Alastair G McEwan, Ulrike Kappler   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis

Journal of the Pakistan Medical Association
The retrospective study was conducted at Baoding No.1 Central Hospital, China, and comprised data from July 2021 to January 2023, and aimed at exploring the relationship of neuron-specific enolase, D-dimer and lactate dehydrogenase with prognosis in ...
Jing Xie, Lu Zhang, Ning Gan
doaj   +1 more source

Increase of optical purtiy of L-lactic produced by engineered Escherichia coli by enhancing anaerobic expression of dld gene [PDF]

Zhongguo niangzao
In order to eliminate D-lactic acid in cheap fermentation raw materials and improve the optical purity of L-lactic acid in fermentation final product, the expression plasmids of D-lactate dehydrogenase gene (dld) with different anaerobic inducible ...
YU Jie, LI Zheng, WANG Jinhua, WANG Yongze, GAO Wa, ZHAO Xiao
doaj   +1 more source