The researchers optimized the concentrations of components in the SNEDDS formulation using a D-optimal mixture design, aiming to achieve favorable physicochemical characteristics like dissolution and droplet size.
Saranya, Palavalasa +2 more
core +1 more source
Mixing design and quality optimization of high-moisture textured vegetable protein
Shipin yu jixieObjectiveTo optimize the overall quality of high-moisture textured vegetable protein products.MethodsThe addition levels of soybean protein isolate, pea protein, wheat protein, and flour were used as experimental factors, with hardness and sensory ...
FAN Jiong +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes. [PDF]
Drug Deliv, 2022 Habib BA, Abdeltawab NF, Salah Ad-Din I.
europepmc +1 more source
Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design
Asian Journal of Chemistry, 2018 Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity).
Kong, W. Y. +5 more
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Biology, Medicine & Natural Product ChemistryThe functional food trend has grown rapidly since the Covid-19 pandemic, including products made from natural ingredients like herbal collagen drinks.
Mutia Hanifa
doaj +1 more source
Optimization of dabi teff-field pea based energy and protein dense novel complementary food with improved sensory acceptability using D-optimal mixture design. [PDF]
Heliyon, 2023 Tura DC, Belachew T, Tamiru D, Abate KH.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Two-stage designs robust to model uncertainty. [PDF]
D-optimal designs are known to depend quite critically on the particular model that is assumed. These designs tend to concentrate all the experimental runs on a small number of design points and are ideally suited for estimating the coefficients of the ...
Ruggoo, Arvind, Vandebroek, Martina
core