Results 1 to 10 of about 3,353 (212)

Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization [PDF]

Pharmaciana, 2021
Black cumin seed oil (MBJH) (Nigella sativa L.) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form.
Rodhia Ulfa, Dwi Utami, Iis Wahyuningsih
doaj   +3 more sources

A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies

Pharmaceuticals, 2020
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as ...
Burcu Mesut, Nedime Serakıncı, Sevgi Güngör   +2 more
exaly   +3 more sources

An in Vitro Study on Anticancer Efficacy of Capecitabine- and Vorinostat-incorporated Self-nanoemulsions [PDF]

Journal of Biomedical Physics and Engineering
Background: Cancer has emerged as a critical global health concern due to its widespread prevalence and impact on individuals, families, communities, and healthcare systems worldwide.Objective: We investigated the anticancer effectiveness of capecitabine
Razieh Nazari-Vanani, Naghmeh Sattarahmady, Khashayar Karimian, Hossein Heli   +3 more
doaj   +2 more sources

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection [PDF]

Nanomaterials, 2021
Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation.
Rabia Arshad, Tanveer A. Tabish, Maria Hassan Kiani, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Misook Kang, Sadanand Pandey   +7 more
doaj   +3 more sources

Development of Alectinib-Suspended SNEDDS for Enhanced Solubility and Dissolution

Pharmaceutics, 2022
Alectinib hydrochloride (ALH), a tyrosine kinase inhibitor, is a practically water-insoluble drug classified as BCS class IV. The present study aimed to develop novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) to enhance the ...
Eun Ji Park, Seung Ah Choi, Kyoung Ah Min, Jun-Pil Jee, Sung Giu Jin, Kwan Hyung Cho   +5 more
doaj   +3 more sources

Fabrication and evaluation of solidified nanoemulsion designs for systemic delivery of atorvastatin through the lung [PDF]

Scientific Reports
To improve the solubility of atorvastatin and overcome the stability issues of liquid nanoemulsion, the current study aimed to synthesize solidified SNEDDS particles with aerodynamic diameter of ≤ 3 μm.
Muhammad Danish Saeed, Kifayat Ullah Shah, Asif Nawaz, Faiqa Falak Naz, Amira Metouekel, Gamal A. Shazly, Musaab Dauelbait   +6 more
doaj   +2 more sources

Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

Acta Pharmaceutica Sinica B, 2019
This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol (CAR), cinnarizine (CIN) or R3040 on drug solubilization in a two-compartment in vitro lipolysis model.
Thomas Rades, Huiling Mu, Kirsten Graeser   +2 more
exaly   +3 more sources

Assessment of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Ethyl Acetate Fraction from Mangosteen (Garcinia mangostana L.,) Peels to Eschericia coli, Pseudomonas aeroginosa, and Proteus mirabilis [PDF]

Majalah Obat Tradisional, 2019
Mangosteen peels have antibacterial activity. SNEDDS has many advantages in developing a drug delivery system to increase the penetration of active compounds. The purpose of this study was to compare the effectiveness of the antibacterial SNEDDS of ethyl
Liza Pratiwi
doaj   +3 more sources

Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan [PDF]

Indonesian Journal of Pharmaceutical Education, 2023
Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and
Muhamad Handoyo Sahumena, Suryani Suryani   +1 more
doaj   +3 more sources

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

European Journal of Pharmaceutical Sciences, 2014
The present study aims at evaluating the ability of a gastro-intestinal in vitro lipolysis model to predict the performance of two lipid formulations and a conventional tablet containing a poorly soluble drug, cinnarizine, in dogs, both in the fasted and fed state. A self-nano-emulsifying drug delivery system (SNEDDS) was either dosed in a hard gelatin
Martin Lau Christiansen, René Holm, Jette Jacobsen   +2 more
exaly   +4 more sources