Formulation and Evaluation of Isorhamnetin SNEDDS for Neuroprotection in Alzheimer's Disease [PDF]
Alzheimer's & DementiaAbstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. The disease is marked by the accumulation of amyloid‐beta plaques and tau tangles, which disrupt neuronal function and lead to cell ...
Panda, Sambita +5 more
europepmc +4 more sources
Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization [PDF]
Pharmaciana, 2021 Black cumin seed oil (MBJH) (Nigella sativa L.) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form.
Rodhia Ulfa, Dwi Utami, Iis Wahyuningsih
doaj +3 more sources
An in Vitro Study on Anticancer Efficacy of Capecitabine- and Vorinostat-incorporated Self-nanoemulsions [PDF]
Journal of Biomedical Physics and EngineeringBackground: Cancer has emerged as a critical global health concern due to its widespread prevalence and impact on individuals, families, communities, and healthcare systems worldwide.Objective: We investigated the anticancer effectiveness of capecitabine
Razieh Nazari-Vanani +3 more
doaj +2 more sources
Development of Alectinib-Suspended SNEDDS for Enhanced Solubility and Dissolution
Pharmaceutics, 2022 Alectinib hydrochloride (ALH), a tyrosine kinase inhibitor, is a practically water-insoluble drug classified as BCS class IV. The present study aimed to develop novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) to enhance the ...
Eun Ji Park +5 more
doaj +3 more sources
Fabrication and evaluation of solidified nanoemulsion designs for systemic delivery of atorvastatin through the lung [PDF]
Scientific ReportsTo improve the solubility of atorvastatin and overcome the stability issues of liquid nanoemulsion, the current study aimed to synthesize solidified SNEDDS particles with aerodynamic diameter of ≤ 3 μm.
Muhammad Danish Saeed +6 more
doaj +2 more sources
Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability [PDF]
PharmaceuticsBackground/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral bioavailability of cannabidiol (CBD).
Fengying Wu +5 more
doaj +2 more sources
Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework [PDF]
PharmaceuticsBackground/Objectives: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been widely applied in oral drug delivery, particularly for poorly water-soluble compounds. The successful development of SNEDDS largely depends on the precise composition of its components.
Sani Ega Priani +4 more
openaire +4 more sources
Pharmaceuticals, 2022 The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS ...
Fabian-Pascal Schmied +2 more
doaj +1 more source
Pharmaceutics, 2022 Background: Solidification by high surface area adsorbents has been associated with major obstacles in drug release. Accordingly, new approaches are highly demanded to solve these limitations.
Ahmad Yousef Tashish +3 more
doaj +1 more source
Profil Ketoksikan Akut SNEDDS Propolis
Jurnal Sains Farmasi & Klinis, 2022 Propolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh.
Arba Pramundita Ramadani +3 more
openaire +1 more source