Results 11 to 20 of about 3,353 (212)

Formulation and Evaluation of Isorhamnetin SNEDDS for Neuroprotection in Alzheimer's Disease [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. The disease is marked by the accumulation of amyloid‐beta plaques and tau tangles, which disrupt neuronal function and lead to cell ...
Panda S, Singh S, Bashir B, Pal B, Vishwas S, Kaur J.   +5 more
europepmc   +4 more sources

Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability [PDF]

Pharmaceutics
Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral bioavailability of cannabidiol (CBD).
Fengying Wu, Qing Ma, Guanghui Tian, Kaixian Chen, Rulei Yang, Jingshan Shen   +5 more
doaj   +2 more sources

Co-encapsulation of docetaxel and cyclosporin A into SNEDDS to promote oral cancer chemotherapy [PDF]

Drug Delivery, 2019
Self-nanoemulsifying drug delivery system (SNEDDS) have been considered as a promising platform for oral delivery of many BCS (biopharmaceutics classification system) class IV drugs, such as docetaxel (DTX).
Weiping Cui, Hanqing Zhao, Chen Wang, Yao Chen, Cong Luo, Shenwu Zhang, Bingjun Sun, Zhonggui He   +7 more
doaj   +3 more sources

THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) [PDF]

INDONESIAN JOURNAL OF PHARMACY, 2017
Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide.
Martien, Ronny, Sugiyanto, Sugiyanto, wahyuningsih, iis -, Yuswanto, Ag.   +3 more
core   +4 more sources

Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework. [PDF]

Pharmaceutics
Background/Objectives: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been widely applied in oral drug delivery, particularly for poorly water-soluble compounds. The successful development of SNEDDS largely depends on the precise composition of its components.
Priani SE, Fakih TM, Wilar G, Chaerunisaa AY, Sopyan I.   +4 more
europepmc   +4 more sources

Enhancing Oral Bioavailability of Apigenin Using a Bioactive Self-Nanoemulsifying Drug Delivery System (Bio-SNEDDS): In Vitro, In Vivo and Stability Evaluations

Pharmaceutics, 2020
Apigenin (APG) is a very well-known flavonoid for its anti-inflammatory and anticancer properties. The purpose of this study is to improve the solubility and bioavailability of APG using a stable bioactive self-nanoemulsifying drug delivery system (Bio ...
Mohsin Kazi, Alshehri, Ehab M Elzayat
exaly   +3 more sources

Characterization of SNEDDS Formulated with Single Bulb Garlic and its Anti-Inflammatory Effect on 3T3-L1 [PDF]

Hayati Journal of Biosciences
Inflammation is an early symptom of a disease that reduces the level of health. Single-bulb garlic (Allium sativum L.) is used medicinally as a plant with a broad pharmacological effect, especially anti-inflammatory activity.
Sri Rahayu Lestari, Sunaryono Sunaryono, Hendra Susanto, Hidajah Rachmawati , Rony Irawanto, Dewi Sekar Miasih, Alif Rosyidah El Baroroh, Yuslinda Annisa, Muhammad Sasmito Djati   +8 more
doaj   +3 more sources

Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers—A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs

Pharmaceuticals, 2022
The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS ...
Fabian-Pascal Schmied, Alexander Bernhardt, Sandra Klein   +2 more
doaj   +1 more source

Adsorbent Precoating by Lyophilization: A Novel Green Solvent Technique to Enhance Cinnarizine Release from Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS)

Pharmaceutics, 2022
Background: Solidification by high surface area adsorbents has been associated with major obstacles in drug release. Accordingly, new approaches are highly demanded to solve these limitations.
Ahmad Yousef Tashish, Ahmad Abdul-Wahhab Shahba, Fars Kaed Alanazi, Mohsin Kazi   +3 more
doaj   +1 more source

Profil Ketoksikan Akut SNEDDS Propolis

Jurnal Sains Farmasi & Klinis, 2022
Propolis memiliki efek imunostimulan yang tinggi namun tidak larut air dan memiliki bioavailabilitas yang rendah. Formulasi propolis dalam bentuk SNEDDS terbukti mampu meningkatkan aktivitas imunostimulannya, namun juga memberikan potensi ketoksikan dikarenakan kecilnya ukuran partikel nano dan akumulasi nya di dalam tubuh.
Arba Pramundita Ramadani, Yandi Syukri, Sherina Nabila Putri Hakim, Annisa Fitria   +3 more
openaire   +1 more source