Results 11 to 20 of about 1,285 (172)

A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies

Pharmaceuticals, 2020
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as ...
Alaa Alghananim, Yıldız Özalp, Burcu Mesut, Nedime Serakinci, Yıldız Özsoy, Sevgi Güngör   +5 more
doaj   +3 more sources

Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

Acta Pharmaceutica Sinica B, 2019
This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol (CAR), cinnarizine (CIN) or R3040 on drug solubilization in a two-compartment in vitro lipolysis model.
ScheylaDaniela Siqueira Jørgensen, Thomas Rades, Huiling Mu, Kirsten Graeser, Anette Müllertz   +4 more
doaj   +3 more sources

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

European Journal of Pharmaceutical Sciences, 2014
The present study aims at evaluating the ability of a gastro-intestinal in vitro lipolysis model to predict the performance of two lipid formulations and a conventional tablet containing a poorly soluble drug, cinnarizine, in dogs, both in the fasted and fed state. A self-nano-emulsifying drug delivery system (SNEDDS) was either dosed in a hard gelatin
Christophersen, Philip Carsten B, Christiansen, Martin Lau, Holm, Rene, Kristensen, Jakob, Jacobsen, Jette, Abrahamsson, Bertil, Müllertz, Anette   +6 more
openaire   +5 more sources

Enhancing Oral Bioavailability of Apigenin Using a Bioactive Self-Nanoemulsifying Drug Delivery System (Bio-SNEDDS): In Vitro, In Vivo and Stability Evaluations

Pharmaceutics, 2020
Apigenin (APG) is a very well-known flavonoid for its anti-inflammatory and anticancer properties. The purpose of this study is to improve the solubility and bioavailability of APG using a stable bioactive self-nanoemulsifying drug delivery system (Bio ...
Mohsin Kazi, Abdullah Alhajri, Sultan M. Alshehri, Ehab M. Elzayat, Osaid T. Al Meanazel, Faiyaz Shakeel, Omar Noman, Mohammad A. Altamimi, Fars K. Alanazi   +8 more
doaj   +3 more sources

Combined Curcumin and Lansoprazole-Loaded Bioactive Solid Self-Nanoemulsifying Drug Delivery Systems (Bio-SSNEDDS)

Pharmaceutics, 2021
Background: The current study aimed to design a novel combination of lansoprazole (LNS) and curcumin (CUR) solid oral dosage form using bioactive self-nanoemulsifying drug delivery systems (Bio-SSNEDDS).
Abdulrahman Alshadidi, Ahmad Abdul-Wahhab Shahba, Ibrahim Sales, Md Abdur Rashid, Mohsin Kazi   +4 more
doaj   +1 more source

Development and Evaluation of Paclitaxel‐Loaded Self‐Nanoemulsifying Drug Delivery System for Enhanced Cancer Therapy: A Promising Alternative to Cremophor EL–Based Formulation [PDF]

IET Nanobiotechnol
Background and Purpose Paclitaxel’s clinical use is limited by poor aqueous solubility and Cremophor EL–related toxicity in commercial formulations. This study aimed to develop a self‐nanoemulsifying drug delivery system (SNEDDS) to improve paclitaxel solubility, bioavailability, and anticancer efficacy.
Almehmady A, Alahmadi A, Hakami A, Ali E, Kalantan A, Aljagthmi A, Ahmed T.   +6 more
europepmc   +2 more sources

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Nanomaterials, 2021
Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation.
Rabia Arshad, Tanveer A. Tabish, Maria Hassan Kiani, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Misook Kang, Sadanand Pandey   +7 more
doaj   +1 more source

Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet

Pharmaceutics, 2022
Pioglitazone Hydrochloride (PGZ) suffers from poor aqueous solubility. The aim of this research was to design orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS) to improve the Pioglitazone solubility and dissolution rate. Three
Mahmoud Teaima, Sandra Hababeh, Mai Khanfar, Fares Alanazi, Doaa Alshora, Mohammed El-Nabarawi   +5 more
doaj   +1 more source

Development and optimization of Ropinirole loaded self-nanoemulsifying tablets

Future Journal of Pharmaceutical Sciences, 2023
Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral ...
Krunal Detholia, Amrutha Mohandas, Umang Varia, Mukesh Jadeja, Hitesh Katariya   +4 more
doaj   +1 more source

Formulasi dan Uji Karakteristik SNEDDS Asiklovir

Majalah Farmasetika, 2021
Asiklovir termasuk ke dalam biopharmaceuticals classification system (BCS) kelas III. Obat yang tergolong ke dalam BCS kelas III memiliki kelarutan tinggi dan permeabilitas rendah. SNEDDS terbukti dapat meningkatkan kelarutan, disolusi dan permeabilitas obat.
Nanda Dwi Akbar, Akhmad Kharis Nugroho, Sudibyo Martono   +2 more
openaire   +2 more sources