Results 101 to 110 of about 24,603 (322)

Numerical construction of maximin optimal designs for binary response models [PDF]

For the binary response model, we determine optimal designs which are robust wit respect to the misspecifications of the unknown parameters. We propose a maximin approach and provide a numerical method to identify the best two point designs for the ...
Biedermann, Stefanie, Dette, Holger
core  

Design Issues for Generalized Linear Models: A Review

, 2006
Generalized linear models (GLMs) have been used quite effectively in the modeling of a mean response under nonstandard conditions, where discrete as well as continuous data distributions can be accommodated.
Ghosh, Malay, Khuri, André I., Mukherjee, Bhramar, Sinha, Bikas K.   +3 more
core   +3 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Subsampling Algorithms for Irregularly Spaced Autoregressive Models

Algorithms
With the exponential growth of data across diverse fields, applying conventional statistical methods directly to large-scale datasets has become computationally infeasible.
Jiaqi Liu, Ziyang Wang, HaiYing Wang, Nalini Ravishanker   +3 more
doaj   +1 more source

Locally D-Optimal Designs for Hierarchical Response Experiments

, 2021
Mingyao Ai, Zhiqiang Ye, Jun Yu
openalex   +1 more source

Optimal solving of a scheduling problem using quantum annealing metaheuristics on the D-Wave quantum solver [PDF]

, 2023
Wojciech Bożejko, Ryszard Klempous, Jarosław Pempera, Jerzy W. Rozenblit, Czesław Smutnicki, Mariusz Uchroński, Mieczysław Wodecki   +6 more
openalex   +1 more source

On the number of D-optimal designs

Journal of Combinatorial Theory, Series A, 1994
The main result of the paper is the theorem: For \(n=18\), there are precisely three essentially different matrices with elements \(\pm 1\) having the maximum determinant. Only one of these is of the circulant type, but all are of the skew type. This means that there are three \(D\)-optimal designs for \(n=18\).
openaire   +2 more sources

Optimal designs for rating-based conjoint experiments. [PDF]

The scope of conjoint experiments on which we focus embraces those experiments in which each of the respondents receives a different set of profiles to rate.
Goos, Peter, Kessels, Roselinde, Vandebroek, Martina   +2 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source