Results 111 to 120 of about 18,707,175 (333)
Optimal designs for rating-based conjoint experiments. [PDF]
The scope of conjoint experiments on which we focus embraces those experiments in which each of the respondents receives a different set of profiles to rate.
Goos, Peter +2 more
core
Approximate D-optimal design and equilibrium measure
We introduce a minor variant of the approximate D-optimal design of experiments with a more general information matrixthat takes into account the representation of the design space S. The main motivation (and result) is that if S in R^d is the unit ball, the unit box or the canonical simplex, then remarkably, for every dimension d and every degree n ...
Henrion, Didier, Lasserre, Jean Bernard
openaire +3 more sources
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Discussion: “Optimum Profile Modifications for the Minimization of Static Transmission Errors of Spur Gears” (Tavakoli, M. S., and Houser, D. R., 1986, ASME J. Mech. Transm. Autom. Des., 108, pp. 86–94) [PDF]
, 1986 R. W. Cornell
openalex +1 more source
Comparing different sampling schemes for approximating the integrals involved in the semi-Bayesian optimal design of choice experiments. [PDF]
In conjoint choice experiments, the semi-Bayesian D-optimality criterion is often used to compute efficient designs. The traditional way to compute this criterion which involves multi-dimensional integrals over the prior distribution is to use Pseudo ...
Goos, Peter +2 more
core
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Accounting for parameter uncertainty in two-stage designs for Phase II dose-response studies [PDF]
Updated version has been published in the book "Modern Adaptive
Randomized Clinical Trials: Statistical and Practical Aspects", 2015, Chapman
and Hall/CRC, p. 427-450, 2014 In this paper we consider two-stage adaptive dose-response study designs, where the study design is changed at an interim analysis based on the information collected so far. In a simulation study, two approaches will be compared for these type of designs; (i) updating the study design by calculating the maximum likelihood estimate for the dose-response
arxiv
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Optimal controller synthesis with D stability [PDF]
, 1994 N. Sivashankar +2 more
openalex +1 more source