Results 61 to 70 of about 21,182,977 (288)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Scientific AfricanIn this paper, we provide novel generalizations of the D-type-I functions by relaxing the D-Preinvexity functions using the mean-valued theorem. Under these new generalizations of the D-Preinvexity type-I functions, we also study the optimality solutions
Mohamed Abd El-Hady Kassem +1 more
doaj +1 more source
Approximating quantum channels by completely positive maps with small Kraus rank [PDF]
QuantumWe study the problem of approximating a quantum channel by one with as few Kraus operators as possible (in the sense that, for any input state, the output states of the two channels should be close to one another).
Cécilia Lancien, Andreas Winter
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Optimal Designs For the Restricted Maximum Likelihood Estimators in a Random Split-Plot Model
Lithuanian Journal of Statistics, 2017 The design effect for the restricted maximum likelihood estimators of variance components in acompletely randomized split-plot model is studied. The model was used to represent the response generated froman experimental scenario where the whole-plot and
Oluwole Nuga, G. N. Amahia, Fatai Salami
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Optimal State Transfer and Entanglement Generation in Power-Law Interacting Systems
Physical Review X, 2021 We present an optimal protocol for encoding an unknown qubit state into a multiqubit Greenberger-Horne-Zeilinger-like state and, consequently, transferring quantum information in large systems exhibiting power-law (1/r^{α}) interactions.
Minh C. Tran +4 more
doaj +1 more source