Results 91 to 100 of about 39,485,272 (291)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Cross media knowledge information retrieval model based on D-S evidence theory

open access: yesSystems and Soft Computing
Cross media knowledge information retrieval provides strong support for information processing and utilization in the information society, but there are problems such as heterogeneity in cross media knowledge information.
Hongbo Li   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Trust Management Scheme Based on D-S Evidence Theory for Wireless Sensor Networks

open access: yesInternational Journal of Distributed Sensor Networks, 2013
Trust management scheme has been regarded as a powerful tool to defend against the wide set of security attacks and identify malicious nodes. In this paper, we propose a trust management scheme based on revised Dempster-Shafer (D-S) evidence theory.
Renjian Feng   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Characterization The Factors Influencing Construction Productivity Using Index System and D-S Evidence Theory

open access: yesWasit Journal of Engineering Sciences
It is a very importance, both theoretically and practically, to create an indicator system to evaluate the factors affecting construction productivity.
Buroog Mahmood, Alaa Khurbat Almosawi
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

High voltage circuit breaker fault diagnosis based on optimized TQWT and D–S evidence theory [PDF]

open access: yesAIP Advances
Vibration signals serve as an important parameter for diagnosing the mechanical fault diagnosis in high-voltage circuit breakers (HVCBs). Influenced by the complicated mechanical structures, transmission paths of mechanical vibrations, and signal ...
Wei Dong   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy